• Publications
  • Influence
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remainsExpand
  • 403
  • 31
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.
We have tested the effects of annexin 1 (ANXA1) and its N-terminal peptide Ac2-26 on polymorphonuclear leukocyte (PMN) recruitment under flow. Differential effects of the full-length protein and itsExpand
  • 216
  • 19
  • Open Access
Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia
The brain microenvironment is continuously monitored by microglia with the detection of apoptotic cells or pathogens being rapidly followed by their phagocytosis to prevent inflammatory responses.Expand
  • 132
  • 13
Microglia Function in Alzheimer’s Disease
Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia, the resident “macrophages” of the brain’s innate immune system, are mostExpand
  • 235
  • 11
  • Open Access
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics.
An innovative avenue for anti-inflammatory therapy is inhibition of neutrophil extravasation by potentiating the action of endogenous anti-inflammatory mediators. The glucocorticoid-inducible proteinExpand
  • 108
  • 9
Lipocortin 1 reduces myocardial ischemia‐reperfusion injury by affecting local leukocyte recruitment
We assessed here the effect of the glucocorticoid‐regulated protein lipocortin 1 (LC1) in a model of rat myocardial ischemia reperfusion. Treatment of animals with human recombinant LC1 at the end ofExpand
  • 81
  • 7
Annexin 1: more than an anti-phospholipase protein
Annexin 1 (ANXA1) is the first characterized member of the annexin family of proteins able to bind (i.e. to annex) to cellular membranes in a calcium-dependent manner. ANXA1 may be induced byExpand
  • 247
  • 6
Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid
Our recent studies on rat pituitary tissue suggest that the annexin 1 (ANXA1)-dependent inhibitory actions of glucocorticoids on ACTH secretion are effected via a paracrine mechanism that involvesExpand
  • 176
  • 4
  • Open Access
A novel calcium‐dependent proapoptotic effect of annexin 1 on human neutrophils
The glucocorticoid‐inducible protein annexin (ANXA) 1 is an anti‐inflammatory mediator that down‐regulates the host response. Endogenously, ANXA1 is released in large amounts from adherentExpand
  • 178
  • 4
Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration.
In this study, we assessed the role of annexin V, a Ca2+-dependent phospholipid-binding protein, as a regulator of protein kinase C (PKC) and characterized its mechanism of inhibition. SeveralExpand
  • 61
  • 4