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Why drinking green tea could prevent cancer
TLDR
It is inferred and subsequently demonstrated that one of the major ingredients of green tea inhibits urokinase, an enzyme crucial for cancer growth.
Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme
Soybean lipoxygenase isoenzyme L3 represents a second example (after L1) of the X‐ray structure (R = 17% at 2.6 Å resolution) for a member of the large family of lipoxygenases. L1 and L3 have
Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review).
TLDR
This review summarizes recent findings on the structure and functional activity of the plasminogen activator inhibitor type-1, and current opinions on its role in tumorigenesis.
Lipoxygenases - A Challenging Problem in Enzyme Inhibition and Drug Development
Lipoxygenases (LOXs), cytochromes P450 (CYPs) and cyclooxygenases (COXs) catalyze peroxidation of unsaturated fatty acids. In humans they convert arachidonic acid into a variety of eicosanoids, which
Structure of curcumin in complex with lipoxygenase and its significance in cancer.
TLDR
This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase, and adds new information to the role thatCurcumin might play in cancer prevention and treatment.
Plasminogen activator inhibitor-1 in kidney pathology (Review).
TLDR
The literature strongly suggests that PAI-1 is a valid target in the treatment of fibrotic renal disease and assessment of prognosis for the diseased kidney should include a variety of proteolysis regulators and enzymes.
Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
TLDR
The isomorphous structures of the hirugen and hirulog 1 (D-Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen) complexes of human alpha-thrombin have been determined and refined.
Three-dimensional structure of a purple lipoxygenase.
TLDR
The structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.
Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.
TLDR
An unoccupied electron mass appears to be an unusual degradation product of curcumin (4-hydroxyperoxy-2-methoxyphenol) located near the soybean L3 catalytic site that may help in the development of novel anti-cancer drugs used for treatment where lipoxygenases are involved.
A study of the anti-diabetic agents of camel milk.
TLDR
Traditional folk remedies in the Middle East are looked into to find if there is any scientific merit to justify their claims for alleviating symptoms of diabetes, and the possibility that insulin in camel milk is present and present in nanoparticles capable of transporting this hormone into the bloodstream.
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