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Administration of fructose 1,6-diphosphate during early reperfusion significantly improves recovery of contractile function in the postischemic heart.
OBJECTIVES Fructose-1,6-diphosphate is a glycolytic intermediate that has been shown experimentally to cross the cell membrane and lead to increased glycolytic flux. Because glycolysis is anExpand
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An evaluation of the integrity of the blood‐testis barrier by magnetic resonance imaging
This present investigation was initiated to noninvasively evaluate the usefulness of intravenous gadopentetate dimeglumine (Gd‐PTDM) ‐enhanced magnetic resonance imaging (MRI) in assessing theExpand
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Isolation, purification and 1H-NMR characterization of a kringle 5 domain fragment from human plasminogen.
A scheme is proposed for generating the intact Val-448-Phe-545 polypeptide of human plasminogen which contains the fifth kringle domain of the plasmin heavy chain. The procedure is based on a pepsinExpand
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Direct detrimental effects of L-arginine upon ischemia--reperfusion injury to myocardium.
The effects of L-arginine on recovery of myocardial contractile function and oxidative metabolism were investigated in a model of reversible global normothermic, ischemic injury using an isolated,Expand
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31P NMR measurements of myocardial pH in vivo.
A 31P NMR magnetization transfer method for measuring myocardial pH in vivo is demonstrated in the lamb, dog and cat. The method involves measuring the difference in chemical shift between theExpand
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Protein kinase C activation in the heart: effects on calcium and contractile proteins.
BACKGROUND Cardiac contractile function is dependent on the energetic state of the heart, intracellular calcium levels, and the interaction of the contractile proteins with both adenosineExpand
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Mitochondrial redox state as a potential detector of liver dysoxia in vivo.
Dysoxia can be defined as ATP flux decreasing in proportion to O2 availability with preserved ATP demand. Hepatic venous beta-hydroxybutyrate-to-acetoacetate ratio (beta-OHB/AcAc) estimates liverExpand
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Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus‐31 nuclear magnetic resonance spectroscopy in vivo
The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus‐31 nuclear magneticExpand
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Improved protection of the hypertrophied left ventricle by histidine-containing cardioplegia.
BACKGROUND Myocardial hypertrophy has been shown to lead to increased susceptibility to ischemia with accelerated loss of high-energy nucleotides, greater accumulation of H+ and lactate, and earlierExpand
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Analysis of the aromatic 1H-NMR spectrum of the kringle 5 domain from human plasminogen. Evidence for a conserved kringle fold.
A kringle 5 domain fragment from human plasminogen has been investigated by 1H-NMR spectroscopy at 300 MHz and 620 MHz. The study focuses on the kringle 5 aromatic spectrum as aromatic side chainsExpand
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