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An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease.
RATIONALE Although cigarette smoking is the most important cause of chronic obstructive pulmonary disease (COPD), a substantial proportion of COPD cases cannot be explained by smoking alone. Expand
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Family‐based tests for associating haplotypes with general phenotype data: Application to asthma genetics
We provide a general purpose family‐based testing strategy for associating disease phenotypes with haplotypes when phase may be ambiguous and parental genotype data may be missing. These tests forExpand
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Genetic Epidemiology of COPD (COPDGene) Study Design
ABSTRACT Background: COPDGene is a multicenter observational study designed to identify genetic factors associated with COPD. It will also characterize chest CT phenotypes in COPD subjects, includingExpand
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Changes in forced expiratory volume in 1 second over time in COPD.
BACKGROUND A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability andExpand
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Characterisation of COPD heterogeneity in the ECLIPSE cohort
BackgroundChronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and wellExpand
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PBAT: tools for family-based association studies.
PBAT is a software package for family-based association studies that provides a software implementation of the approaches to analytical power calculations for FBATs, as well as data analysis of such studies. Expand
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Chronic obstructive pulmonary disease phenotypes: the future of COPD.
Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). Although FEV(1) inadequately describes this heterogeneity, aExpand
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A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin,Expand
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Estimation and Tests of Haplotype-Environment Interaction when Linkage Phase Is Ambiguous
In the study of complex traits, the utility of linkage analysis and single marker association tests can be limited for researchers attempting to elucidate the complex interplay between a gene andExpand
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Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. ToExpand
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