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Stochastic Gene Expression in a Single Cell
Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can be essential for many biological processes and is conjectured to arise from stochasticity, or noise, inExpand
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Entropic elasticity of lambda-phage DNA.
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Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis
The mechanisms of localization and retention of membrane proteins in the inner nuclear membrane and the fate of this membrane system during mitosis were studied in living cells using the innerExpand
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Regulatory element detection using correlation with expression
We present here a new computational method for discovering cis-regulatory elements that circumvents the need to cluster genes based on their expression profiles. Based on a model in which upstreamExpand
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Intrinsic and extrinsic contributions to stochasticity in gene expression
Gene expression is a stochastic, or “noisy,” process. This noise comes about in two ways. The inherent stochasticity of biochemical processes such as transcription and translation generatesExpand
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Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells
Quantitative time-lapse imaging data of single cells expressing the transmembrane protein, vesicular stomatitis virus ts045 G protein fused to green fluorescent protein (VSVG–GFP), were used forExpand
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Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells
The Golgi complex is a dynamic organelle engaged in both secretory and retrograde membrane traffic. Here, we use green fluorescent protein–Golgi protein chimeras to study Golgi morphology in vivo. InExpand
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PhyloGibbs: A Gibbs Sampling Motif Finder That Incorporates Phylogeny
We present a new motif sampling algorithm, PhyloGibbs, that runs on arbitrary collections of multiple local sequence alignments of orthologous sequences. Expand
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Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing
The spread of multidrug-resistant Staphylococcus aureus (MRSA) strains in the clinical environment has begun to pose serious limits to treatment options. Yet virtually nothing is known about howExpand
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High Rayleigh Number Convection
Turbulent convection exemplifies many of the startling aspects of turbulent flows that have been uncovered in the past two decades, but frequently exhibits a novel twist. Thus, as in the case of freeExpand
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