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Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice
Humanized BLT mice accurately develop human HIV-specific CD8+ T cell responses capable of rapidly selecting for CTL escape mutations. Mirror, Mirror One limitation of using animal models of diseaseExpand
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Neutralizing anti-HIV antibodies develop in a humanized mouse model of HIV-1 infection
Background In BLT (bone marrow-liver-thymus) humanized mice, human thymocytes are educated by autologous human thymic tissue, resulting in functional human T cells capable of rapidly selecting forExpand