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- Publications
- Influence
Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice
- Timothy E. Dudek, Daniel No, +14 authors T. Allen
- Biology, Medicine
- Science Translational Medicine
- 18 July 2012
Humanized BLT mice accurately develop human HIV-specific CD8+ T cell responses capable of rapidly selecting for CTL escape mutations. Mirror, Mirror One limitation of using animal models of disease… Expand
Modification of immune activation in HIV-1-infected humanized mouse model using TLR7/9 antagonists
- J. Chang, R. Lindsay, +7 authors M. Altfeld
- Biology
- 1 May 2012
Neutralizing anti-HIV antibodies develop in a humanized mouse model of HIV-1 infection
Background In BLT (bone marrow-liver-thymus) humanized mice, human thymocytes are educated by autologous human thymic tissue, resulting in functional human T cells capable of rapidly selecting for… Expand