Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
- I. Hill, M. Dirks, E. Seidman
- MedicineJournal of Pediatric Gastroenterology and…
- 2005
It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for Celiac disease have a blood test for antibody to tissue transglutaminase (TTG), and that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and treated with a strict gluten-free diet.
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease.
- M. Dubinsky, S. Lamothe, E. Seidman
- Medicine, BiologyGastroenterology
- 1 April 2000
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
- M. Dubinsky, Huiying Yang, E. Vasiliauskas
- Medicine, BiologyGastroenterology
- 1 April 2002
Serial metabolite monitoring identifies a novel phenotype of IBD patients resistant to 6-MP/AZA therapy biochemically characterized by suboptimal 6-TGN and preferential 6-MMPR production upon dose escalation.
Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease*
- Tian-tian Wang, B. Dabbas, John H. White
- Biology, MedicineJournal of Biological Chemistry
- 30 November 2009
Hormonal vitamin D, 1,25-dihydroxyvitamin D3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells, providing strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition.
Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus.
- A. Bourreille, A. Ignjatovic, A. van Gossum
- MedicineEndoscopy
- 1 July 2009
This document sets out the current Consensus reached by a group of international experts in the fields of endoscopy and IBD at a meeting held in Brussels, 12-13th December 2008, organised jointly by the European Crohn's and Colitis Organisation (ECCO) and the Organisation Mondiale d'Endoscopie Digestive (OMED).
The three-gene paraoxonase family: physiologic roles, actions and regulation.
- Louis-philippe Precourt, D. Amre, E. Levy
- BiologyAtherosclerosis
- 2011
Pathogenesis of Shiga Toxin-Associated Hemolytic Uremic Syndrome
- F. Proulx, E. Seidman, D. Karpman
- Medicine, BiologyPediatric Research
- 1 August 2001
The aim of this review is to examine recent advances in experimental and clinical research relevant to the pathogenesis of diarrhea-associated hemolytic uremic syndrome with special reference to…
Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change
- I. Gralnek, R. Defranchis, E. Seidman, J. Leighton, P. Legnani, B. Lewis
- MedicineAlimentary Pharmacology and Therapeutics
- 23 October 2007
This manuscript documents the development of a validated index for capsule endoscopy findings and states that this index is likely to be applicable to small bowel mucosal inflammatory change.
Association of host genome with intestinal microbial composition in a large healthy cohort
- W. Turpin, O. Espin-Garcia, K. Croitoru
- BiologyNature Genetics
- 3 October 2016
It is found that almost one-third of fecal bacterial taxa were heritable, and 58 SNPs associated with the relative abundance of 33 taxa in 1,098 discovery subjects remained significant after correction for multiple testing.
Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease.
- F. Ruemmele, S. Targan, G. Levy, M. Dubinsky, J. Braun, E. Seidman
- Medicine, BiologyGastroenterology
- 1 October 1998
ASCA and pANCA assays are highly disease specific for CD and UC, respectively, and may be useful in making therapeutic decisions in patients with IBD and without IBD.
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