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The tight junction: a multifunctional complex.
TLDR
A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity.
Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification.
TLDR
The incidence of acute humoral rejection in renal allograft biopsies has been difficult to determine because widely accepted diagnostic criteria have not been established and non-HLA antibodies or subthreshold levels of DSA were detected in posttransplant recipient sera.
Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases
TLDR
Results show that RhoA and Rac1 regulate gate and fence functions of the TJ, and play a role in the spatial organization of TJ proteins at the apex of the lateral membrane.
Occludin is a functional component of the tight junction.
TLDR
To test whether expression of chick occludin affected the process of tight junction assembly, monolayers in low Ca2+ medium were treated with isopropyl- beta-D-thiogalactoside for 24 or 48 hours, before Ca2+.
Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries.
TLDR
C4d can be used to separate this group of CR from the nonspecific category of chronic allograft nephropathy and may have the potential to guide successful therapeutic intervention and support the hypothesis that a substantial fraction of CR is mediated by antibody (immunologically active).
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.
TLDR
The data suggest that occludin transduces external (apoptotic cells) and intramembrane (rapid cholesterol depletion) signals via a Rho signaling pathway that, in turn, elicits reorganization of the actin cytoskeleton.
Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.
TLDR
C4d in peritubular capillary walls distinguishes AHR from ACR, is more specific and sensitive than traditional criteria, and is a potentially valuable adjunct in the diagnosis of graft dysfunction.
VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells.
TLDR
Functional evidence that VIP17/MAL, a tetraspan membrane protein localized to post-Golgi transport containers and the apical cell surface in MDCK cells, is involved in apical transport and might be a component of the machinery clustering lipid rafts with apical cargo to form apicals transport carriers is provided.
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex.
TLDR
The data show that CLDN16 interacts with CLDN19 and that their association confers a TJ with cation selectivity, suggesting a mechanism for the role of mutant forms of CL DN16 and CL DN19 in the development of FHHNC.
Structure, function, and regulation of cellular tight junctions.
TLDR
Until the biochemical composition of this structure has been defined and its gene identified, the TJ will continue to be an elusive yet tantalizing challenge to the cell biologist.
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