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International study of factors affecting human chromosome translocations.

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The Effect of 29 kV X Rays on the Dose Response of Chromosome Aberrations in Human Lymphocytes

A special survey of the RBEM values obtained by different investigators in the narrow quality range from about 30 to 350 kV X rays indicates that the present RBE is in fairly good agreement with previously published findings for the induction of chromosome aberrations or micronuclei in human lymphocytes but differs from recently published findingsFor neoplastic transformation in a human hybrid cell line.
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Radiation-induced chromosome aberrations analysed by two-colour fluorescence in situ hybridization with composite whole chromosome-specific DNA probes and a pancentromeric DNA probe.

The linear quadratic calibration curve generated for total stable translocations is based on approx.
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LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes.

Measurements of intrachanges are informative for interpretation and quantification of proximity effects in the formation of radiation-induced chromosome aberrations, and yield ratios for intra-arm intrachange are likely to have a high potential as an indicator of high-LET radiations.
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Perturbation of cell division by acrylamide in vitro and in vivo.

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Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells

The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments, as well as the standard error bands of the dose response curves.
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Cell survival and radiation induced chromosome aberrations

Human peripheral lymphocytes were irradiated in whole blood with 0.5–4.0 Gy of 220 kVp X-rays and the frequency of chromosome aberrations was determined in lst or 2nd division metaphases discriminated by fluorescence plus giemsa staining, indicating that cell reproductive death is overestimated in the latter approach.
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Dicentric chromosomes in monolayers of human lymphocytes produced by monochromatized synchrotron radiation with photon energies from 1.83 keV to 17.4 keV

A systematic approach was used to examine the induction of dicentric chromosomes in human lymphocytes irradiated in vitro with monochromatized synchrotron radiation produced with photon energies in the range from 1.83 keV to 17.4  keV, and results agree in essence with the previously published large data set from Sasaki's laboratory.
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Analysis of chromosome aberrations in human peripheral lymphocytes induced by 5.4 keV x-rays

A technique that has been developed in the laboratory is used to ensure uniformity of irradiation within lymphocytes and to avoid artefacts due to the cell cycle kinetics in this irradiation experiment on 3-h-stimulated lymphocytes.
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Radiation-induced chromosome aberrations analysed by fluorescence in situ hybridization with a triple combination of composite whole chromosome-specific DNA probes.

Fluorescence in situ hybridization (FISH) with a combination of three composite whole chromosome-specific DNA probes for human chromosomes 1, 4 and 12 was used to analyse in vitro radiation-induced…
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