• Publications
  • Influence
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations.Expand
  • 3,343
  • 173
  • PDF
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary arteryExpand
  • 3,108
  • 166
  • PDF
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body massExpand
  • 2,623
  • 160
  • PDF
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations betweenExpand
  • 2,014
  • 151
  • PDF
An integrated map of structural variation in 2,504 human genomes
Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classesExpand
  • 1,389
  • 112
  • PDF
Genetics of gene expression surveyed in maize, mouse and man
Treating messenger RNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been pursued in gene-specific ways. Transcript abundancesExpand
  • 1,508
  • 78
  • PDF
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks.Expand
  • 1,074
  • 72
  • PDF
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis ofExpand
  • 1,272
  • 58
  • PDF
New genetic loci link adipose and insulin biology to body fat distribution
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of bodyExpand
  • 906
  • 51
  • PDF
Tissue-specific expression and regulation of sexually dimorphic genes in mice.
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ.Expand
  • 714
  • 50
  • PDF
...
1
2
3
4
5
...