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Wnt signalling regulates adult hippocampal neurogenesis
The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the subgranularExpand
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Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
  • X. Zhao, T. Ueba, +11 authors F. Gage
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 14 May 2003
DNA methylation-mediated epigenetic regulation plays critical roles in regulating mammalian gene expression, but its role in normal brain function is not clear. Methyl-CpG binding protein 1 (MBD1), aExpand
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Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3‐dimensional reconstruction
The morphology of neurons in the main divisions of the hippocampal complex allow the easy identification of granule cells in the dentate gyrus and pyramidal cells in the CA1 and CA3 regions ofExpand
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Transcriptional profiling reveals strict boundaries between hippocampal subregions
The hippocampus consists of distinct anatomic regions that have been demonstrated to have different biological functions. To explore the molecular differences between hippocampal subregions, weExpand
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A Genetic Method for Selective and Quickly Reversible Silencing of Mammalian Neurons
Genetic methods for neuronal silencing have great promise for allowing selective inactivation of specific cell types within complex neural systems. Present methods, however, are limited in theirExpand
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Selective and Quickly Reversible Inactivation of Mammalian Neurons In Vivo Using the Drosophila Allatostatin Receptor
Genetic strategies for perturbing activity of selected neurons hold great promise for understanding circuitry and behavior. Several such strategies exist, but there has been no direct demonstrationExpand
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Molecular and Anatomical Signatures of Sleep Deprivation in the Mouse Brain
Sleep deprivation (SD) leads to a suite of cognitive and behavioral impairments, and yet the molecular consequences of SD in the brain are poorly understood. Using a systematic immediate-early geneExpand
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Adolescent mental health—Opportunity and obligation
Emerging neuroscience offers hope for treatments The adolescent brain is more “plastic” than it will ever be again, capable of remarkable adaptability in light of the many social, physical, sexual,Expand
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Dynamic regulation of BDNF and NT‐3 expression during visual system development
Recent studies have proposed roles for neurotrophins in the formation and plasticity of ocular dominance columns as well as in the regulation of dendritic arborization in visual cortex of higherExpand
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Rapid Regulation of Brain-Derived Neurotrophic Factor mRNA within Eye-Specific Circuits during Ocular Dominance Column Formation
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a candidate retrograde signaling molecule for geniculocortical axons during the formation of ocular dominance columns. Here weExpand
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