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Modulation of Bleomycin-Induced Lung Fibrosis by Pegylated Hyaluronidase and Dopamine Receptor Antagonist in Mice
Hyaluronidases are groups of enzymes that degrade hyaluronic acid (HA). To stop enzymatic hydrolysis we modified testicular hyaluronidase (HYAL) by activated polyethylene oxide with the help ofExpand
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Catecholamine regulation of stromal precursors and hemopoietic stem cells in cytostatic myelosuppression
Effects of a sympatholytic drug on bone marrow stromal and hemopoietic precursors were studied on the model of cyclophosphamide-induced myelosuppression. Sympatholytic treatment increased the contentExpand
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Anti-fibrotic Effects of Reserpine on Lung Fibrosis: Stem Cells in the Pathogenesis of Pneumofibrosis
In this study was found that inflammation in interstitial lung tissue of mice C57Bl/6 after intratracheal injection of the bleomycin is accompanied by the increase of the bone marrow and circulatingExpand
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Effects and Mechanisms of Hemopoiesis-Stimulating Activity of Immobilized Oligonucleotides under Conditions of Cytostatic Myelosuppression
Hemopoiesis-stimulating activity of immobilized oligonucleotide preparation was studied on the model of cytostatic myelosuppression induced by injection of cyclophosphamide and 5-fluorouracil.Expand
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Role of Sertoli and Leydig Cells in the Regulation of Spermatogonial Stem Cell and Development of Reproductive Disorders in Male C57Bl/6 Mice with Type 1 Diabetes Mellitus
Course administration streptozotocin to male C57Bl/6 mice induces a complex of symptoms typical of type 1 diabetes mellitus: hyperglycemia and insulin deficiency, focal inflammatory infiltration ofExpand
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Antifibrotic Effect of Combined Treatment with Neuroleptic Drug and Immobilized Hyaluronidase in Pulmonary Fibrosis
Using the model of lung fibrosis induced by intratracheal administration of bleomycin we studied anti-fibrotic activity of combined treatment with neuroleptic haloperidol and hyaluronidaseExpand
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Effect of Antiserotonin Drug on the Development of Lung Fibrosis and Blood System Reactions after Intratracheal Administration of Bleomycin
The effects of antiserotonin preparation on the development of the connective tissue in the lungs, reaction of the blood system, and the content of hemopoietic stem cells, committed hemopoietic andExpand
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Reactions of the blood system and stem cells in bleomycin-induced model of lung fibrosis
On the model of toxic diffuse pulmonary fibrosis induced by intratracheal administration of bleomycin, we studied reactions of the blood system, content of stem cells, committed hemopoietic andExpand
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Differentiation of Pancreatic Stem and Progenitor β-Cells into Insulin Secreting Cells in Mice with Diabetes Mellitus
We studied in vitro differentiation of pancreatic stem and progenitor cells into insulin secreting cells in the model of streptozotocin-induced diabetes in C57Bl/6 mice. Streptozotocin was shown toExpand
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Antifibrotic Activity of Hyaluronidase Immobilized on Polyethylenoxide under Conditions of Bleomycin-Induced Pneumofibrosis
Hyaluronidase immobilized on polyethylenoxide obtained by electron bean synthesis was administered intranasally and intravenously to C57Bl/6 mice after intratracheal bleomycin and the enzyme effectsExpand
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