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A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
A mechanism whereby snake venoms produce pain is revealed, and an unexpected contribution of ASIC1 channels to nociception is highlighted, raising the possibility that ASIC channels function as coincidence detectors for extracellular protons and other, as yet unidentified, endogenous factors.
Molecular Basis of Infrared Detection by Snakes
TRPA1 orthologues from pit-bearing snakes are the most heat-sensitive vertebrate ion channels thus far identified, consistent with their role as primary transducers of infrared stimuli, and illustrate the broad evolutionary tuning of transient receptor potential (TRP) channels as thermosensors in the vertebrate nervous system.
The Deep Origin and Recent Loss of Venom Toxin Genes in Rattlesnakes
Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona.
Snake venomics of Crotalus tigris: the minimalist toxin arsenal of the deadliest Nearctic rattlesnake venom. Evolutionary Clues for generating a pan-specific antivenom against crotalid type II venoms…
- J. Calvete, Alicia Pérez, B. Lomonte, E. Sánchez, L. Sanz
- BiologyJournal of proteome research
- 9 January 2012
The data suggest that the evolutionary trend toward neurotoxicity, which has been also reported for the South American rattlesnakes, may have resulted by pedomorphism, and the feasibility of generating a pan-American anti-Crotalus type II antivenom is indicated by the identification of shared evolutionary trends among South and North American Crotalus species.
Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox.
The efficacy of two antivenoms against the venom of North American snakes.
Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon.
Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion
The present study describes the isolation and characterization of a disintegrin (colombistatin) found in the venom of the Venezuelan snake mapanare, which could be used as a therapeutic tool in the treatment of melanoma cancers and also thrombotic diseases.