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Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
CONTEXT Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine, an α(2)-agonist available for ICU sedation, may reduce the durationExpand
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Costs of care, long-term prognosis and quality of life in patients requiring renal replacement therapy during intensive care
Abstract. Objective: To assess (1) the long-term outcome of patients requiring renal replacement therapy (RRT) in terms of 6-month and 5-year mortality, (2) quality of life and (3) costs of theExpand
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The effect of carbon dioxide, respiratory rate and tidal volume on human heart rate variability
Background:  Heart rate variability (HRV) has been used for assessment of depth of anesthesia. Alterations in respiratory rate and tidal volume modulate the sympatovagal neural drive to the heart.Expand
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A Prospective, Randomized Study of Goal-Oriented Hemodynamic Therapy in Cardiac Surgical Patients
Organ dysfunction and multiple organ failure are the main causes of prolonged hospital stay after cardiac surgery, which increases resource use and health care costs. Increased levels of oxygenExpand
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Acute respiratory distress syndrome: frequency, clinical course, and costs of care.
OBJECTIVE To define the occurrence rate of acute respiratory distress syndrome (ARDS) using established criteria in a well-defined general patient population, to study the clinical course of ARDSExpand
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Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study
ObjectiveTo evaluate the incidence, treatment and mortality of acute respiratory failure (ARF) in Finnish intensive care units (ICUs).Study designProspective multicentre cohort study.MethodsAll adultExpand
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Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation
PurposeTo compare dexmedetomidine (DEX) with standard care (SC, either propofol or midazolam) for long-term sedation in terms of maintaining target sedation and length of intensive care unit (ICU)Expand
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Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study
ObjectiveTo determine the incidence and outcome of severe sepsis in the adult Finnish population and to evaluate how treatment guidelines in severe sepsis are applied in clinical practice.StudyExpand
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The effects of ICU admission and discharge times on mortality in Finland
ObjectiveHospital mortality increases if acutely ill patients are admitted to hospitals on weekends as compared with weekdays. Night discharges may increase mortality in intensive care unit (ICU)Expand
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Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study
PurposeWe aimed to determine the incidence, risk factors and outcome of acute kidney injury (AKI) in Finnish ICUs.MethodsThis prospective, observational, multi-centre study comprised adult emergencyExpand
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