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Axon guidance at the midline choice point
The central nervous system (CNS) of higher organisms is bilaterally‐symmetric. The transfer of information between the two sides of the nervous system occurs through commissures formed by neuronsExpand
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Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide.
Cytoplasmic sequestration of wild-type p53 protein occurs in a subset of primary human tumors including breast cancer, colon cancer, and neuroblastoma (NB). The sequestered p53 localizes to punctateExpand
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Caenorhabditis elegans VEM-1, a Novel Membrane Protein, Regulates the Guidance of Ventral Nerve Cord-Associated Axons
In the developing CNS, pathfinding growth cones use intermediate target- and pioneer axon-associated guidance cues to navigate along stereotypical trajectories. We previously showed that the novelExpand
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  • Open Access
Cloning and Expression of VEMA: A Novel Ventral Midline Antigen in the Rat CNS
A variety of molecules expressed at the midline of the developing central nervous system (CNS) control multiple aspects of pattern formation and axon guidance. We recently identified monoclonalExpand
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Axon guidance at the midline of the developing CNS
Bilaterally symmetric animals must be capable of transmitting information between the left and right sides of their body to integrate sensory input and to coordinate motor control. Thus, many neuronsExpand
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New cell surface marker of the rat floor plate and notochord
Regionally expressed cell surface molecules are thought to mediate contact‐dependent interactions that regulate pattern formation and axon pathfinding in the developing vertebrate central nervousExpand
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Calcium Ionophore-Induced Degradation of Neurofilament and Cell Death in MSN Neuroblastoma Cells
Extensive necrotic death of MSN neuroblastoma cells could be induced after incubation with the calcium ionophore, A23187. The reaction was concentration-dependent and time course-dependent. Levels ofExpand
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Expression of Vema in the developing mouse spinal cord and optic chiasm
A critical phase of nervous system development is the formation of connections between axons and their synaptic targets. Intermediate targets play important roles in axon pathfinding by supplyingExpand
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