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Air1 Zinc Knuckles 4 and 5 and a Conserved IWRXY Motif Are Critical for the Function and Integrity of the Trf4/5-Air1/2-Mtr4 Polyadenylation (TRAMP) RNA Quality Control Complex*
In Saccharomyces cerevisiae, non-coding RNAs, including cryptic unstable transcripts (CUTs), are subject to degradation by the exosome. The Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) complex in S.Expand
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Recent advances in the structural mechanisms of DNA glycosylases.
DNA glycosylases safeguard the genome by locating and excising a diverse array of aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the discovery 28years ago thatExpand
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An unprecedented nucleic acid capture mechanism for excision of DNA damage
DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same time confound cancer alkylation therapy, by excisingExpand
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An HPLC-tandem mass spectrometry method for simultaneous detection of alkylated base excision repair products.
DNA glycosylases excise a broad spectrum of alkylated, oxidized, and deaminated nucleobases from DNA as the initial step in base excision repair. Substrate specificity and base excision activity areExpand
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A new protein architecture for processing alkylation damaged DNA: the crystal structure of DNA glycosylase AlkD.
DNA glycosylases safeguard the genome by locating and excising chemically modified bases from DNA. AlkD is a recently discovered bacterial DNA glycosylase that removes positively chargedExpand
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Nucleic acid recognition by tandem helical repeats.
Protein domains constructed from tandem α-helical repeats have until recently been primarily associated with protein scaffolds or RNA recognition. Recent crystal structures of human mitochondrialExpand
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Differences in the Curing of [PSI+] Prion by Various Methods of Hsp104 Inactivation
[PSI +] yeast, containing the misfolded amyloid conformation of Sup35 prion, is cured by inactivation of Hsp104. There has been controversy as to whether inactivation of Hsp104 by guanidine treatmentExpand
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Oxidation and Glycolytic Cleavage of Etheno and Propano DNA Base Adducts†
Non-invasive strategies for the analysis of endogenous DNA damage are of interest for the purpose of monitoring genomic exposure to biologically produced chemicals. We have focused our research onExpand
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Structural Studies of Alkylpurine DNA Glycosylases
Alkylation of DNA bases produces a broad spectrum of cytotoxic and mutagenic lesions that are removed from the genome by alkylpurine DNA glycosylases. These DNA repair enzymes exist in eukaryotes,Expand
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The substrate binding interface of alkylpurine DNA glycosylase AlkD.
Tandem helical repeats have emerged as an important DNA binding architecture. DNA glycosylase AlkD, which excises N3- and N7-alkylated nucleobases, uses repeating helical motifs to bind duplex DNAExpand
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