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The complete genome sequence of the Gram-positive bacterium Bacillus subtilis
Bacillus subtilis is the best-characterized member of the Gram-positive bacteria, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.
Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
An important adaptive role for metabolism diversification within group B2 and Shigella strains is found, but few or no extraint intestinal virulence-specific genes are identified, which could render difficult the development of a vaccine against extraintestinal infections.
Mobility of Plasmids
- C. Smillie, M. P. Garcillán-Barcia, M. Francia, E. Rocha, F. de la Cruz
- BiologyMicrobiology and Molecular Biology Reviews
- 1 September 2010
A computational protocol was established to identify and classify conjugation and mobilization genetic modules in 1,730 plasmids, suggesting the existence of unsuspected new relaxases in archaea and new conjugations systems in cyanobacteria and actinobacteria.
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
This study integrated human epidemiological and clinical data with bacterial population genomics to harness the biodiversity of the model foodborne pathogen Listeria monocytogenes and decipher the basis of its neural and placental tropisms.
The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients
The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen, and Pseudogenes in virulence determinants suggest that the pathogenic response of J 2315 may have been recently selected to promote persistence in the CF lung.
Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes
This work demonstrates the urgent need to monitor Lm strains at the global level and provides the unified approach needed for global harmonization of Lm genome-based typing and population biology.
Comparative and Evolutionary Analysis of the Bacterial Homologous Recombination Systems
Using comparative genomics, the diversity of recombination processes among bacteria is assessed, and simulations suggest that the assessment of the intrinsic stability or recombination isolation of bacteria in most cases cannot be inferred from the identification of known recombination proteins in the genomes.
CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins
The program includes an improved CRISPR array detection tool facilitating expert validation based on a rating system, prediction ofCRISPR orientation and a Cas protein detection and typing tool updated to match the latest classification scheme of these systems.
The Systemic Imprint of Growth and Its Uses in Ecological (Meta)Genomics
It is shown that one can predict maximal growth rates from sequence data alone, and it is proposed that such information can be used to facilitate the manipulation of generation times.
Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125.
The analysis of the genome sequence of the fast growing Antarctica bacterium Pseudoalteromonas haloplanktis TAC125 finds that it copes with the increased solubility of oxygen at low temperature by multiplying dioxygen scavenging while deleting whole pathways producing reactive oxygen species.