Role of insulin-like growth factors in embryonic and postnatal growth
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
Teratocarcinomas and embryonic stem cells : a practical approach
- E. Robertson
The results allowed us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Parental imprinting of the mouse insulin-like growth factor II gene
Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection
It is demonstrated that the T-box transcription factors T-bet and Eomesodermin differentially regulate two phenotypically and functionally distinct subsets of antiviral CD8+ T cells in mice, which may be important for antiviral immunity during chronic viral infections in humans.
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
Findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development and disrupts the subsequent cellular interactions required for their continued growth and development.
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning in the early mammalian embryo.
Nodal signalling in the epiblast patterns the early mouse embryo
- J. Brennan, Cindy C. Lu, D. Norris, T. Rodríguez, R. Beddington, E. Robertson
- 21 June 2001
The experiments show that proximal–distal and subsequent anterior–posterior polarity of the pregastrulation embryo result from reciprocal cell–cell interactions between the epiblast and the two extra-embryonic tissues.
Relationship between asymmetric nodal expression and the direction of embryonic turning
It is observed in inv mutant embryos8 that the sidedness of nodal expression correlates with the direction of heart looping and embryonic turning, demonstrating that elements of the genetic pathway that establish the left–right body axis are conserved in vertebrates.