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Role of insulin-like growth factors in embryonic and postnatal growth
A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor (IGF1R), alone or… Expand
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
- Jeh-Ping Liu, Julie B. Baker, Archlbald S. Perkins, E. Robertson, A. Efstratiadis
- Biology, Medicine
- 8 October 1993
Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar in severity to that previously observed in viable Igf-2 null mutants… Expand
Parental imprinting of the mouse insulin-like growth factor II gene
We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygous… Expand
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety… Expand
Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection
Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative… Expand
Relationship between asymmetric nodal expression and the direction of embryonic turning
GROWTH factors related to TGF-β provide important signals for patterning the vertebrate body plan1–3. One such family member, nodal, is required for formation of the primitive streak during mouse… Expand
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo.… Expand
Axis Development and Early Asymmetry in Mammals
We thank Peter Rigby and Tristan Rodriguez for their helpful discussion and apologize to all those whose work has not been cited due to space constraints.
Pitx2 determines left–right asymmetry of internal organs in vertebrates
The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is expressed in the left… Expand