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Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems,Expand
Chemical characterization of sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice.
Sicilian cultivars of prickly pear were partially characterized from a chemical point of view, and the possibility of long-term storage of their juice was investigated, finding Pectin methylesterase (PME) seems to be present in very small amount and/or is not highly active. Expand
Nitric oxide in cell survival: a janus molecule.
The current understanding of the cytotoxic versus cytoprotective effects of NO in the central nervous system is reviewed, highlighting the Janus-faced properties of this small molecule. Expand
β-Amyloid Monomers Are Neuroprotective
Synthetic Aβ1-42 monomers support the survival of developing neurons under conditions of trophic deprivation and protect mature neurons against excitotoxic death, a process that contributes to the overall neurodegeneration associated with AD. Expand
Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity
The importance of vitagenes in the cellular stress response and the potential use of dietary antioxidants in the prevention and treatment of neurodegenerative disorders is discussed. Expand
Neuroprotective features of carnosine in oxidative driven diseases.
Beneficial effects on most of the common biochemical events that characterize neurological disorders make carnosine a very promising molecule among all the endogenous compounds in the treatment and/or prevention of oxidative driven diseases. Expand
Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice
It is found that carnosine supplementation in 3xTg-AD mice promotes a strong reduction in the hippocampal intraneuronal accumulation of Aβ and completely rescues AD and aging-related mitochondrial dysfunctions. Expand
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.
How hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases is described in mechanistic detail. Expand
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity.
The most current and up to date understanding of the possible signaling mechanisms by which caloric restriction, as well hormetic caloric restriction-mimetics compounds by activating vitagenes can enhance defensive systems involved in bioenergetic and stress resistance homeostasis with consequent impact on longevity processes is discussed. Expand
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: a spectroscopic and voltammetric study.
Results taken together suggest that peptide 1 provides a single metal binding site to which copper(II) binds strongly at neutral and basic pH and that the binding of the metal induces the formation of a stiffened structure in the HGGG peptide fragment. Expand