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Bioactive analogs of neurotensin: Focus on CNS effects
Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract. It is closely associated anatomically with dopaminergic and otherExpand
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Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.
BACKGROUND/AIMS Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edemaExpand
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The effects of systemic NT69L, a neurotensin agonist, on baseline and drug-disrupted prepulse inhibition
Centrally administered neurotensin (NT) produces behavioral and biochemical effects that are very similar to the effects of antipsychotic drugs. Therefore, there is much interest in the potential useExpand
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Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an α1 agonist
RationaleNeurotensin (NT) agonists have been proposed as potential antipsychotics based exclusively upon their ability to inhibit dopamine-2 (D2) receptor transmission. Several other pharmacologicalExpand
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A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats
NT69L is a neurotensin analog that blocks nicotine-induced locomotor activity and has sustained efficacy in a rat model of nicotine-induced sensitization when administered peripherally. Additionally,Expand
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The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex
Schizophrenia is a life-long, severe, and disabling brain disorder that requires chronic pharmacotherapy. Because current antipsychotic drugs do not provide optimal therapy, we have been developingExpand
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Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice
Neurotensin (NT) is a tridecapeptide that acts as a neuromodulator in the central nervous system mainly through two NT receptors, NTS1 and NTS2. The functional-anatomical interactions between NT, theExpand
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Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action.
Organic cation transporter 3 (OCT3, SLC22A3) is a low-affinity, high-capacity transporter widely expressed in the central nervous system (CNS) and other major organs in both humans and rodents. It isExpand
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Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.
Most currently prescribed antidepressants act by selectively increasing the synaptic availability of serotonin or norepinephrine, or through action on both serotonin and norepinephrine. However, mostExpand
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The Rat Neurotensin Receptor Expressed in Chinese Hamster Ovary Cells Mediates the Release of Inositol Phosphates
Abstract: To study second messenger synthesis mediated by the cloned rat neurotensin receptor, we derived a cell line stably expressing this receptor. The cDNA clone of this receptor was subclonedExpand
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