• Publications
  • Influence
Homocysteine, folate, methylation, and monoamine metabolism in depression
OBJECTIVES Previous studies suggest that folate deficiency may occur in up to one third of patients with severe depression, and that treatment with the vitamin may enhance recovery of the mentalExpand
  • 477
  • 14
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM eitherExpand
  • 226
  • 7
Folic acid, ageing, depression, and dementia
  • E. Reynolds
  • Medicine
  • BMJ : British Medical Journal
  • 22 June 2002
It is becoming clear that folic acid affects mood and cognitive function, especially in older people. Edward Reynolds draws together the evidence Folic acid is important for functioning of theExpand
  • 189
  • 6
Enhancement of recovery from psychiatric illness by methylfolate.
  • 141
  • 6
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.
Recent studies have shown that most newly diagnosed epileptic patients can be satisfactorily treated with a single antiepileptic drug. We therefore undertook a prospective randomised pragmatic trialExpand
  • 230
  • 5
The neurology of folic acid deficiency.
The metabolism of folic acid and the metabolism of vitamin B12 are intimately linked such that deficiency of either vitamin leads to an identical megaloblastic anemia. The neurologic manifestationsExpand
  • 47
  • 5
The prognosis for seizure control in newly diagnosed epilepsy.
We assessed the prognosis for seizure control in 106 patients who were referred to an adult neurology clinic with previously untreated tonic-clonic, partial, or mixed seizures and were followedExpand
  • 198
  • 4
Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam.
Fifteen patients with a variety of myoclonic syndromes were studied clinically, pharmacologically, and physiologically. CSF tryptophan, 5HIAA, and HVA were also measured. Of these patients, 8 wereExpand
  • 116
  • 4
Predictive Value of Interictal Epileptiform Discharges During Non‐REM Sleep on Scalp EEG Recordings for the Lateralization of Epileptogenesis
Summary: Purpose: EEG recording during sleep is widely used in the assessment of epilepsy, particularly in candidates for surgery, yet the diagnostic value of this procedure is not well established.Expand
  • 69
  • 4