• Publications
  • Influence
Homocysteine, folate, methylation, and monoamine metabolism in depression
A biological subgroup of depression with folate deficiency, impaired methylation, and monoamine neurotransmitter metabolism has been identified and Detection of this subgroup, which will not be achieved by routine blood counts, is important in view of the potential benefit of vitamin replacement. Expand
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment. Expand
Folic acid, ageing, depression, and dementia
  • E. Reynolds
  • Medicine
  • BMJ : British Medical Journal
  • 22 June 2002
Edward Reynolds draws together the evidence that folic acid is important for functioning of the nervous system at all ages, and suggests a link between folic Acid, homocysteine, ageing, depression, and dementia, including Alzheimer's disease and vascular disease. Expand
The neurology of folic acid deficiency.
Folates and vitamin B12 have fundamental roles in central nervous system function at all ages, especially in purine, thymidine, neucleotide, and DNA synthesis, genomic and nongenomic methylation and, therefore, in tissue growth, differentiation and repair. Expand
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.
In patients with newly diagnosed tonic-clonic or partial with or without secondary generalised seizures, the choice of drug will be more influenced by considerations of toxicity and costs. Expand
Enhancement of recovery from psychiatric illness by methylfolate.
Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery and added to the evidence implicating disturbances of methylation in the nervous system in the biology of some forms of mental illness. Expand
Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam.
The neurochemical basis of myoclonus responding to 5HT precursors and clonazepam is discussed and it is suggested that such myOClonus arises from a relative hypoactivity of the 5HT neuronal system which results in a release of abnormal responses to sensory stimuli which characterize this type of my Coclonus. Expand
The neuropsychiatry of megaloblastic anaemia.
The neuropsychiatry of megaloblastic anaemia seen in this study of patients presenting to haematologists or general physicians contrasts with that reported previously, before haem atological techniques for separating the two deficiencies were introduced. Expand
The prognosis for seizure control in newly diagnosed epilepsy.
The long-term pattern of seizure control is largely established during the first two years of treatment, with patients with previously untreated tonic-clonic, partial, or mixed seizures having a better prognosis. Expand
Chronic Antiepileptic Toxicity: A Review
The role of Folic Acid Deficiency and Vitamin B1 Metabolism in Nonanemic Epileptic Patients, and Predisposing Factors, are discussed. Expand