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In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19.
The specific cytochrome P450 (P450) isoforms mediating the biotransformations of clobazam (CLB) and those of its major metabolites, N-desmethylclobazam (NCLB) and 4'-hydroxyclobazam were identifiedExpand
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Drug Disposition in Cystic Fibrosis
There are many pathological changes in patients with cystic fibrosis (CF) which can lead to alterations in drug disposition.Although, in patients with CF, the extent of drug absorption varies widelyExpand
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Vigabatrin. Clinical pharmacokinetics.
Vigabatrin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacologicalExpand
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IN VITRO AND IN VIVO INHIBITORY EFFECT OF STIRIPENTOL ON CLOBAZAM METABOLISM
A metabolic interaction between stiripentol (STP), an anticonvulsant agent that inhibits the activity of several cytochromes P450 (P450s), and clobazam (CLB), a 1,5-benzodiazepine, used inExpand
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Stiripentol: Efficacy and Tolerability in Children with Epilepsy
Summary: Purpose: Stiripentol (STP) is a new antiepileptic drug (AED) that inhibits cytochrome P450′ resulting in increased plasma concentrations of concomitant AEDs. The efficacy and tolerability ofExpand
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Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid chromatography with ultra-violet detection.
A sensitive and selective high-performance liquid chromatographic (HPLC) method with ultra-violet detection has been developed and validated for the simultaneous determination of posaconazole andExpand
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[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)].
OBJECTIVE To describe the long term efficacy and tolerance of stiripentol associated with valproate and clobazam in an exhaustive cohort of patients with severe myoclonic epilepsy of infancyExpand
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Pharmacokinetics and toxicity of docetaxel: Role of CYP3A, MDR1, and GST polymorphisms
Patients initiating docetaxel chemotherapy were genotyped for CYP3A4, CYP3A5, MDR1, GSTM1, GSTT1, GSTM3, and GSTP1 to identify variability factors of docetaxel pharmacokinetics and toxicity.
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Maternal-Fetal Transfer and Amniotic Fluid Accumulation of Nucleoside Analogue Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pregnant Women
ABSTRACT This study was performed to investigate placental transfer of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and their concentrations in amniotic fluid when given to humanExpand
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Lamotrigine in Treatment of 120 Children with Epilepsy
Summary: One hundred twenty children aged 10 months to 16 years 9 months were included in three studies with lamotrigine (LTG): a single‐blind study (n = 60), a pharmacokinetic study (n = 23), and aExpand
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