• Publications
  • Influence
Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.
TLDR
The chemical composition of the Caribbean sponge Pandaros acanthifolium was reinvestigated and led to the isolation of 12 new steroidal glycosides, namely, pandarosides E-J and their methyl esters (7-12), which showed in vitro activity against three or four parasitic protozoa. Expand
Composition and Biological Properties of the Volatile Oil of Artemisia gorgonum Webb
TLDR
The volatile oil of this endemic plant was tested for its antioxidant and antimalarial properties, and was found to exhibit free‐radical scavenging on 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), prevention of lipid peroxidation–in vitro by TBARS (thiobarbituric acid reactive species) assay, and antiplasmodial activity. Expand
Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B
TLDR
This is the first report of an ASIC-current inhibitor derived of a marine-plant extract, and in a phenolic compound, and the active components of the extract are able to cross the blood-brain barrier. Expand
Chromatographic resolution of closely related species: separation of warfarin and hydroxylated isomers.
TLDR
Modifications of results obtained from conventional achiral and chiral chromatography method development screening platforms afford rapid separation of all components for both achirical and Chiral analysis, with supercritical fluid chromatography showing the best performance in both cases. Expand
Repair of UVB-Damaged Skin by the Antioxidant Sulphated Flavone Glycoside Thalassiolin B Isolated from the Marine Plant Thalassia testudinum Banks ex König
TLDR
Topical application of the aqueous ethanolic extract of the marine sea grass on mice skin exposed to UVB radiation resulted in a dose-dependent recovery of the skin macroscopic alterations over a 6-day period, suggesting that thalassiolin B is responsible for the skin-regenerating effects of the crude extract. Expand
Phytochemical Analysis and Antioxidant Capacity of BM-21, a Bioactive Extract Rich in Polyphenolic Metabolites from the Sea Grass Thalassia testudinum
TLDR
This is the first study which highlights the phytochemical composition of BM-21 and demonstrates that this product is a rich source of natural antioxidants with potential applications in pharmaceutical, cosmetic and food industries. Expand
Ultrafast Chiral Chromatography as the Second Dimension in Two-Dimensional Liquid Chromatography Experiments.
TLDR
This investigation into the use of ultrafast chiral chromatography as a second dimension for 2D chromatographic separations of chiral and achiral drugs and metabolites, constitutional isomers, stereoisomers, and organohalogenated species is reported. Expand
Chromatographic resolution of closely related species in pharmaceutical chemistry: dehalogenation impurities and mixtures of halogen isomers.
TLDR
A survey of the suitability of four chromatographic method development platforms (ultra high-performance liquid chromatography, core shell HPLC, achiral supercritical fluid chromatography (SFC) and chiral SFC) for separating closely related mixtures of halogens and their dehalogenated isosteres is described. Expand
Improved chiral SFC screening for analytical method development.
TLDR
The greatly improved gradient dwell volume and liquid flow control of the new instrument in combination with the use of shorter columns containing smaller stationary phase particles affords chiral SFC method development that is faster and more universal than previous systems. Expand
Supercritical fluid chromatography for GMP analysis in support of pharmaceutical development and manufacturing activities.
TLDR
This study investigates the use of modern SFC for enantiopurity analysis of several pharmaceutical intermediates and compares the results with the conventional HPLC approaches historically used for analysis in a GMP setting, showing that modern S FC now exhibits improved precision, reproducibility, accuracy and robustness. Expand
...
1
2
3
4
5
...