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The biosynthesis of adenosylcobalamin (vitamin B12).
TLDR
This review provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl).
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Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum
Abstract. The biosynthesis of cobalamin (vitamin B12) is described, revealing how the concerted action of around 30 enzyme-mediated steps results in the synthesis of one of Nature's most structurally…
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The Biosynthesis of Adenosylcobalamin (Vitamin B12)
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Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon.
TLDR
It was concluded that B. megaterium, M. jannaschii and Synechocystis sp.
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Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli
TLDR
The finding that S. typhimurium cbiL mutants are not complemented with the homologous Pseudomonas denitrificans gene lends further credence to the theory that cobalt is required at an early stage in the biosynthesis of cobalamins in S. Typhimurial.
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Identification and Characterization of a Novel Vitamin B12 (Cobalamin) Biosynthetic Enzyme (CobZ) from Rhodobacter capsulatus, Containing Flavin, Heme, and Fe-S Cofactors*
TLDR
Recombinant overproduction of Orf663, now renamed CobZ, allowed the characterization of a novel cofactor-rich protein, housing two Fe-S centers, a flavin, and a heme group, which like B12 itself is a modified tetrapyrrole.
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A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis
TLDR
Results suggest that CbiK can function in fashion analogous to that of the N-terminal domain of CysG (CysG(B)), which catalyzes the final two steps in siroheme synthesis, i.e., NAD-dependent dehydrogenation of precorrin-2 to sirohydrochlorin and ferrochelation.
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Vitamin B12: Insights into Biosynthesis's Mount Improbable
TLDR
The sequences of these enzymes reveal that they are clearly related, most likely having evolved from an ancestral methylase gene, and parallels with the chelatases found in heme and chlorophyll synthesis are drawn.
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Characterization of the Cobaltochelatase CbiXL
TLDR
Redox potentiometry coupled with optical spectroscopy allowed the midpoint potential of the redox center to be determined for the CbiXL from both B. megaterium and Synechocystis and confirmed the presence of an iron-sulfur center.
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Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis.
TLDR
The X-ray structure of the anaerobic cobalt chelatase from Salmonella typhimurium, CbiK, has been solved to 2.4 A resolution and the protein structure is homologous to that of Bacillus subtilis PPIX ferrochelatase, which has implications for the understanding of the evolution of this branched biosynthetic pathway.
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