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d-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors
TLDR
Physiological studies in rats and salamanders demonstrated that, in retinal ganglion cells, d-serine can enhance excitatory currents elicited by the application of NMDA, as well as the NMDA receptor component of light-evoked synaptic responses, raising the possibility that endogenous d-Serine serves as a ligand for setting the sensitivity ofNMDA receptors under physiological conditions. Expand
Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina.
TLDR
The results strongly support the concept that endogenous D-serine plays an essential role as a coagonist for NMDARs, allowing them to contribute to the light-evoked responses of retinal ganglion cells. Expand
Glycine transport accounts for the differential role of glycine vs. d‐serine at NMDA receptor coagonist sites in the salamander retina
In this study, we demonstrate that d‐serine interacts with N‐methyl‐d‐aspartate receptor (NMDAR) coagonist sites of retinal ganglion cells of the tiger salamander retina by showing that exogenousExpand
Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina
TLDR
This is the first report of a linkage between D-serine synthesis and NMDA receptor activity in the vertebrate retina. Expand
Effect of ondansetron, a 5-HT3 receptor antagonist, on the dynamic association between bulimic behaviors and pain thresholds
TLDR
The findings that ONDAN treatment is associated with a significant moderation of both variables support the involvement of a common underlying mechanism driving both the increase in pain detection thresholds and the occurrence of the next bulimic episode. Expand
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