• Publications
  • Influence
Stress and the brain: from adaptation to disease
TLDR
New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals.
Corticosteroids Operate as a Switch between Memory Systems
TLDR
It is suggested that a stress-induced switch from hippocampus-based to nucleus caudate-based memory systems can rescue performance, and corticosteroids promote the transition from spatial to stimulus–response memory systems.
Glucocorticoid Receptor Blockade Normalizes Hippocampal Alterations and Cognitive Impairment in Streptozotocin-Induced Type 1 Diabetes Mice
TLDR
It is concluded that hippocampal disruption and cognitive impairment at the early stage of diabetes are caused by excessive GR activation due to hypercorticism and can be prevented and/or reversed by GR blockade with mifepristone.
Acute Activation of Hippocampal Glucocorticoid Receptors Results in Different Waves of Gene Expression Throughout Time
TLDR
Direct activation of GR in hippocampal slices results in transient changes in gene expression, suggesting that the fast genomic effects of glucocorticoids may be realised via transrepression, preceding a later wave of transactivation.
...
...