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Stress and the brain: from adaptation to disease
New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals.
Stress and cognition: are corticosteroids good or bad guys?
The postnatal development of the hypothalamic–pituitary–adrenal axis in the mouse
Corticosteroids Operate as a Switch between Memory Systems
- L. Schwabe, H. Schächinger, E. R. Kloet, M. Oitzl
- Biology, PsychologyJournal of Cognitive Neuroscience
- 1 July 2010
It is suggested that a stress-induced switch from hippocampus-based to nucleus caudate-based memory systems can rescue performance, and corticosteroids promote the transition from spatial to stimulus–response memory systems.
Glucocorticoid signaling and stress-related limbic susceptibility pathway: About receptors, transcription machinery and microRNA
Glucocorticoid Receptor Blockade Normalizes Hippocampal Alterations and Cognitive Impairment in Streptozotocin-Induced Type 1 Diabetes Mice
It is concluded that hippocampal disruption and cognitive impairment at the early stage of diabetes are caused by excessive GR activation due to hypercorticism and can be prevented and/or reversed by GR blockade with mifepristone.
Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling
Gene expression and function of interleukin I, interleukin 6 and tumor necrosis factor in the brain
Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour
Acute Activation of Hippocampal Glucocorticoid Receptors Results in Different Waves of Gene Expression Throughout Time
Direct activation of GR in hippocampal slices results in transient changes in gene expression, suggesting that the fast genomic effects of glucocorticoids may be realised via transrepression, preceding a later wave of transactivation.