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Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor Published, JLR Papers in Press, August 1, 2004. DOI 10.1194/jlr.M400257-JLR200
TLDR
Cell-based studies indicate that DMHCA enhances cholesterol efflux in macrophages and suggest a mechanism whereby this selective modulator can potentially inhibit cholesterol accumulation, and may have application to the study and treatment of atherosclerosis. Expand
Human apolipoprotein A-IV. Intestinal origin and distribution in plasma.
TLDR
It is demonstrated that apoA-IV is present in human intestinal epithelial cells and is secreted as a chylomicron and VLDL apoprotein. Expand
Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype.
TLDR
ApoE genotype has significant and opposite effects on plasma CETP and HDL-C responses to dietary cholesterol in men. Expand
Mechanism of cholesteryl ester transfer protein inhibition by a neutralizing monoclonal antibody and mapping of the monoclonal antibody epitope.
TLDR
The TP2 monoclonal antibody inhibits lipid transfer by blocking the uptake of lipid by CETP by localized to a hydrophobic 26-amino acid sequence at the COOH terminus of CETP. Expand
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]
TLDR
Way-252623 (LXR-623) is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR−/− atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. Expand
Organization of the human cholesteryl ester transfer protein gene.
TLDR
Comparison of the CETP sequence with sequence databases revealed a striking identity of a pentapeptide sequence (ValLeuThrLeuAla) within the hydrophobic core of the signal sequences of human CETP, apolipoproteins A-IV and A-I, and lipoprotein lipase, suggesting that it may mediate a specialized function related to lipid metabolism or transport. Expand
Liver X Receptor (LXR)-β Regulation in LXRα-Deficient Mice: Implications for Therapeutic Targeting
TLDR
Selective LXRβ activation is expected to stimulate ABCA1 gene expression in macrophages, contribute to favorable HDL increases, but circumvent hepatic LXRα-dominated lipogenesis. Expand
Alternative splicing of the mRNA encoding the human cholesteryl ester transfer protein.
TLDR
The experiments show that the expression of the human CETP gene is modified by alternative splicing of the ninth exon, in a tissue-specific fashion, which could serve to produce a protein with a function other than plasma neutral lipid transfer, or as an on-off switch to regulate the local concentration of biologically active protein. Expand
Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.
TLDR
Selective LXRbeta activation is expected to stimulate ABCA1 gene expression in macrophages, contribute to favorable HDL increases, but circumvent hepatic LXRalpha-dominated lipogenesis. Expand
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
TLDR
Peripheral blood cells express LXRα and LXRβ, and respond to LXR agonist treatment by time- and dose-dependently inducing LXR target genes, suggesting LXR gene regulation in blood has the potential to function as a marker of tissue gene regulation. Expand
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