E. Pukkala

Publications957
h-index110
Citations54,937
Highly Influential Citations2,067
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Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
TLDR
Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.
Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study
Cancer risk in mutation carriers of DNA‐mismatch‐repair genes
TLDR
The tumour spectrum associated with germline mutations of DNA‐mismatch‐repair genes involves 8 or more organ sites, suggesting a need to develop methods to screen for extra‐colonic cancer also.
Inherited susceptibility to uterine leiomyomas and renal cell cancer
TLDR
It is shown that predisposition to uterine leiomyomas and papillary renal cell cancer can be inherited dominantly through the hereditaryLeiomyomatosis and renal cell cancers (HLRCC) gene.
Occupation and cancer – follow-up of 15 million people in five Nordic countries
TLDR
Mesothelioma was the cancer type showing the largest relative differences between the occupations, and plumbers, seamen and mechanics were the occupations with the highest risk in the present study.
Second cancers among 40,576 testicular cancer patients: focus on long-term survivors.
TLDR
Testicular cancer survivors are at statistically significantly increased risk of solid tumors for at least 35 years after treatment, and young patients may experience high levels of risk as they reach older ages.
Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease.
TLDR
Hormonal stimulation appears important for the development of radiation-induced breast cancer, as evidenced by the reduced risk associated with ovarian damage from alkylating agents or radiation.
Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease.
TLDR
Past treatments with alkylating agents and radiation therapy for Hodgkin's disease were associated with an increased risk of lung cancer in a dose-dependent and additive fashion, but the precise risk estimates should be interpreted cautiously, given the possible residual and enhancing effects of tobacco.
Incidence of cancer among persons with schizophrenia and their relatives.
TLDR
Although specific lifestyle factors, particularly tobacco smoking and alcohol consumption, probably account for the increased cancer risk in patients with schizophrenia, the decreased risk in relatives would be compatible with a postulated genetic risk factor for schizophrenia offering selective advantage to unaffected relatives.
Hopelessness and Risk of Mortality and Incidence of Myocardial Infarction and Cancer
TLDR
It is indicated that hopelessness is a strong predictor of adverse health outcomes, independent of depression and traditional risk factors, in middle-aged men from the Kuopio Ischemic Heart Disease study.
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