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Extensive Cortical Rewiring after Brain Injury
The results suggest that M1 injury results in axonal sprouting near the ischemic injury and the establishment of novel connections within a distant target, and support the hypothesis that, after a cortical injury, such as occurs after stroke, cortical areas distant from the injury undergo major neuroanatomical reorganization. Expand
Effects of Repetitive Motor Training on Movement Representations in Adult Squirrel Monkeys: Role of Use versus Learning
It is concluded that repetitive motor activity alone does not produce functional reorganization of cortical maps and is proposed that motor skill acquisition, or motor learning, is a prerequisite factor in driving representational plasticity in M1. Expand
Role of adaptive plasticity in recovery of function after damage to motor cortex
These findings have strong clinical relevance as it has recently been shown that after injury to the motor cortex, as might occur in stroke, post‐injury behavioral experience may play an adaptive role in modifying the functional organization of the remaining, intact cortical tissue. Expand
Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery.
It is suggested that neurophysiologic reorganization of remote cortical areas occurs in response to cortical injury and that the greater the damage to reciprocal intracortical pathways, the great the plasticity in intact areas. Expand
In Search of the Motor Engram: Motor Map Plasticity as a Mechanism for Encoding Motor Experience
Evidence that motor map topography reflects the capacity for skilled movement, motor skill learning induces reorganization of motor maps in a manner that reflects the kinematics of acquiredskilled movement, and the role of motor map plasticity in recovery of motor function after brain damage is discussed are reviewed. Expand
Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates
Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury. Expand
Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey.
Data suggest that, at least in squirrel monkeys, descending output from M1 and dorsal and ventral premotor cortices is not necessary for SMA representations to be maintained and that SMA motor output maps undergo delayed increases in representational area after damage to other motor areas. Expand
Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.
The results suggest that after a lesion in the M1 DFL, the induction of representational plasticity in PMv, as evaluated using intracortical microstimulation, is related more to the size of the lesion than to the disruption of its intrACortical connections. Expand
Ipsilateral connections of the ventral premotor cortex in a new world primate
The present study describes the pattern of connections of the ventral premotor cortex (PMv) with various cortical regions of the ipsilateral hemisphere in adult squirrel monkeys. Particularly, we 1)Expand
Neuronal HIF-1α Protein and VEGFR-2 Immunoreactivity in Functionally Related Motor Areas following a Focal M1 Infarct
While remote areas undergo a molecular response to the infarct, it is hypothesized that there is a delay in the initiation of the response, which ultimately may increase the ‘window of opportunity’ for neuroprotective interventions in the intact cortex. Expand