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NF-kappaB functions as a tumour promoter in inflammation-associated cancer.
It is shown that the inflammatory process triggers hepatocyte NF-kappaB through upregulation of tumour-necrosis factor-alpha (TNFalpha) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
NF-κB functions as a tumour promoter in inflammation-associated cancer
It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
There are major unmet needs in HCC management that might be addressed through the discovery of new therapies and their combinations for use in the adjuvant setting and for intermediate- and advanced-stage disease.
Pathogenesis of Acute Viral Disease Induced in Fish by Carp Interstitial Nephritis and Gill Necrosis Virus
The virus causing the disease from sick fish, propagated it in koi fin cell culture, and shown that virus from a single clone causes lethal disease in carp and koi upon infection are called carp interstitial nephritis and gill necrosis virus.
Oct-3/4 is a dose-dependent oncogenic fate determinant.
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
- M. Darash-Yahana, E. Pikarsky, A. Peled
- Medicine, BiologyFASEB journal : official publication of the…
- 1 August 2004
High levels of the chemokine receptor CX CR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer.
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
It is found that hepatic ELSs indicated poor prognosis for hepatocellular carcinoma (HCC), and they constituted immunopathological microniches wherein malignant hepatocyte progenitor cells appeared and thrived in a complex cellular and cytokine milieu until gaining self-sufficiency.
This Primer summarizes the current knowledge on the epidemiology, pathogenetic mechanisms and diagnosis of HCC and provides an update on key advancements in the management of this disease.
The immunology of hepatocellular carcinoma
- M. Ringelhan, D. Pfister, T. O'Connor, E. Pikarsky, M. Heikenwalder
- Medicine, BiologyNature Immunology
- 29 January 2018
The roles of specific immune cell subsets in chronic liver disease, with a focus on non-alcoholic steatohepatitis and HCC are summarized and the challenges posed by the immunotolerant hepatic environment are discussed.