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Extinction Learning in Humans Role of the Amygdala and vmPFC
Understanding how fears are acquired is an important step in translating basic research to the treatment of fear-related disorders. However, understanding how learned fears are diminished may be evenExpand
Preventing the return of fear in humans using reconsolidation update mechanisms
Recent research on changing fears has examined targeting reconsolidation. During reconsolidation, stored information is rendered labile after being retrieved. Pharmacological manipulations at thisExpand
Performance on Indirect Measures of Race Evaluation Predicts Amygdala Activation
We used fMRI to explore the neural substrates involved in the unconscious evaluation of Black and White social groups. Specifically, we focused on the amygdala, a subcortical structure known to playExpand
Emotion and cognition: insights from studies of the human amygdala.
  • E. Phelps
  • Psychology, Medicine
  • Annual review of psychology
  • 2006
Traditional approaches to the study of cognition emphasize an information-processing view that has generally excluded emotion. In contrast, the recent emergence of cognitive neuroscience as anExpand
Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future
The prevailing neurocircuitry models of anxiety disorders have been amygdalocentric in form. The bases for such models have progressed from theoretical considerations, extrapolated from research inExpand
Lesions of the human amygdala impair enhanced perception of emotionally salient events
Commensurate with the importance of rapidly and efficiently evaluating motivationally significant stimuli, humans are probably endowed with distinct faculties and maintain specialized neuralExpand
Human emotion and memory: interactions of the amygdala and hippocampal complex
  • E. Phelps
  • Medicine, Psychology
  • Current Opinion in Neurobiology
  • 1 April 2004
The amygdala and hippocampal complex, two medial temporal lobe structures, are linked to two independent memory systems, each with unique characteristic functions. In emotional situations, these twoExpand
Classical fear conditioning in the anxiety disorders: a meta-analysis.
Fear conditioning represents the process by which a neutral stimulus comes to evoke fear following its repeated pairing with an aversive stimulus. Although fear conditioning has long been consideredExpand
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Research on the neural systems underlying emotion in animal models over the past two decades has implicated the amygdala in fear and other emotional processes. This work stimulated interest inExpand
Activation of the left amygdala to a cognitive representation of fear
We examined the neural substrates involved when subjects encountered an event linked verbally, but not experientially, to an aversive outcome. This instructed fear task models a primary way humansExpand