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- Publications
- Influence
Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345*
- K. Jiang, E. Pereira, Melissa D. Maxfield, B. Russell, D. Goudelock, Y. Sánchez
- Biology, Medicine
- Journal of Biological Chemistry
- 4 July 2003
Checkpoints are biochemical pathways that provide the cell with mechanisms to detect DNA damage and respond by arresting the cell cycle to allow DNA repair. The conserved checkpoint kinase Chk1… Expand
ATRMec1 Phosphorylation-independent Activation of Chk1 in Vivo*
- Y. Chen, J. Caldwell, E. Pereira, R. Baker, Y. Sánchez
- Biology, Medicine
- Journal of Biological Chemistry
- 2 January 2009
The conserved protein kinase Chk1 is a player in the defense against DNA damage and replication blocks. The current model is that after DNA damage or replication blocks, ATRMec1 phosphorylates Chk1… Expand
Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes.
- A. Tada, E. Pereira, D. Beitner-Johnson, R. Kavanagh, Z. Abdel-Malek
- Biology, Medicine
- The Journal of investigative dermatology
- 1 February 2002
In normal human melanocytes various mitogens activate the mitogen-activated protein kinases ERK1/2 and the downstream transcription factor CREB (Ca2+/cAMP response element binding protein).… Expand
Regulatory Interactions between the Checkpoint Kinase Chk1 and the Proteins of the DNA-dependent Protein Kinase Complex*
- D. Goudelock, K. Jiang, E. Pereira, B. Russell, Y. Sánchez
- Biology, Medicine
- Journal of Biological Chemistry
- 8 August 2003
Checkpoints are biochemical pathways that provide cells a mechanism to detect DNA damage and respond by arresting the cell cycle to allow DNA repair. The conserved checkpoint kinase, Chk1, regulates… Expand
Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain
- E. Pereira, Y. Chen, Y. Sánchez
- Biology, Medicine
- Cell cycle
- 1 June 2009
Chk1 is a conserved kinase that comprises the first line of defense against DNA damage and replication blocks. Chk1 consists of two primary domains, the well conserved N-terminal kinase domain and… Expand