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Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345*
Checkpoints are biochemical pathways that provide the cell with mechanisms to detect DNA damage and respond by arresting the cell cycle to allow DNA repair. The conserved checkpoint kinase Chk1Expand
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ATRMec1 Phosphorylation-independent Activation of Chk1 in Vivo*
The conserved protein kinase Chk1 is a player in the defense against DNA damage and replication blocks. The current model is that after DNA damage or replication blocks, ATRMec1 phosphorylates Chk1Expand
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Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes.
In normal human melanocytes various mitogens activate the mitogen-activated protein kinases ERK1/2 and the downstream transcription factor CREB (Ca2+/cAMP response element binding protein).Expand
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Regulatory Interactions between the Checkpoint Kinase Chk1 and the Proteins of the DNA-dependent Protein Kinase Complex*
Checkpoints are biochemical pathways that provide cells a mechanism to detect DNA damage and respond by arresting the cell cycle to allow DNA repair. The conserved checkpoint kinase, Chk1, regulatesExpand
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Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain
Chk1 is a conserved kinase that comprises the first line of defense against DNA damage and replication blocks. Chk1 consists of two primary domains, the well conserved N-terminal kinase domain andExpand
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