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Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
Disruption of the estrogen receptor in humans need not be lethal and is important for bone maturation and mineralization in men as well as women.
Neuroserpin, a Brain-associated Inhibitor of Tissue Plasminogen Activator Is Localized Primarily in Neurons
- G. Hastings, T. Coleman, D. Lawrence
- Biology, ChemistryThe Journal of Biological Chemistry
- 26 December 1997
Data suggest that neuroserpin is likely to be a critical regulator of tPA activity in the central nervous system, and as such may play an important role in neuronal plasticity and/or maintenance.
Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility.
In situ hybridizations show that sp4 is highly expressed in mouse embryos in the developing central nervous system (CNS), andGene targeting by homologous recombination was used to determine the role of sp4 during mouse development, indicating that this gene is required for normal male reproductive behavior.
Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.
Findings from the patient and mice suggest that the absence of functional ER is not lethal, and a single patient is described who is homozygous for a point mutation in the human ER gene at codon 157, which results in estrogen insensitivity syndrome.
Insulin-like growth factor binding protein-3 secretion from cultured rat sertoli cells: dual regulation by follicle stimulating hormone and insulin-like growth factor-I.
The data reveal that the IGFBPs are expressed in a cell type specific manner in the testis, and the opposing effects of FSH and IGF-I on Sertoli cell IGFBP-3 expression suggests a mechanism by which the IGF- I biological activity on SERToli cell might be influenced.
RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response.
Genes coding for proteins involved in the immune response and in intracellular signal transduction pathways activated by cytokines and chemokines were strongly represented, indicating a critical role of RET/PTC3 in the early modulation of theimmune response.
Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man.
The absence of functional estrogen receptors may be a novel risk factor for coronary artery disease in men with estrogen insensitivity caused by a disruptive mutation in the estrogen-receptor gene.
Insulin-like growth factor (IGF) binding protein 3 in the rat testis: follicle-stimulating hormone dependence of mRNA expression and inhibition of IGF-I action on cultured Sertoli cells.
Results show that FSH treatment of rat Sertoli cells dose-dependently decreased IGFBP-3 mRNA, with near-complete inhibition by 12 h of treatment, and that this binding protein has a physiological role in modulating insulin-like growth factor-I activity in the testis.
Immunoreactive sites and accumulation of somatomedin-C in rat Sertoli-spermatogenic cell co-cultures.
Partial characterization of a somatomedin-like peptide from the medium of cultured rat Sertoli cells.
It is demonstrated that rat Sertoli cells in culture secrete a peptide that is the rat equivalent of human Sm-C/IGF-I.