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Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct… Expand
Tetrahymena as a laboratory organism: useful strains, cell culture, and cell line maintenance.
Publisher Summary A key to the usefulness of Tetrahymena as a laboratory organism is its exceptionally fast growth rate under simple and inexpensive culture conditions. With a doubling time under 2… Expand
Tetrahymena Metallothioneins Fall into Two Discrete Subfamilies
Background Metallothioneins are ubiquitous small, cysteine-rich, multifunctional proteins which can bind heavy metals. Methodology/Principal Findings We report the results of phylogenetic and gene… Expand
Dual capacity for nutrient uptake in Tetrahymena. IV. Growth without food vacuoles and its implications.
Abstract A mutant of Tetrahymena pyriformis , syngen 1, having heat-sensitive development of its oral apparatus, can be grown without food vacuole formation indefinitely by supplementing standard… Expand
Transcriptome Analysis of the Model Protozoan, Tetrahymena thermophila, Using Deep RNA Sequencing
Background The ciliated protozoan Tetrahymena thermophila is a well-studied single-celled eukaryote model organism for cellular and molecular biology. However, the lack of extensive T. thermophila… Expand
Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome
The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic genome. Here, we present a complete… Expand
Microarray Analyses of Gene Expression during the Tetrahymena thermophila Life Cycle
Background The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan whose genome has been sequenced, enabling genome-wide analysis of gene expression. Methodology/Principal… Expand
The Ecological Regulation of Species Diversity
A model is proposed to account for the level of diversity supported by any ecological community. If we begin with a hypothetical increase in the stability of the physical environment, the following… Expand
Tetrahymena thermophila, a unicellular eukaryote with separate germline and somatic genomes.
Tetrahymena thermophila is a ciliate--a unicellular eukaryote. Remarkably, every cell maintains differentiated germline and somatic genomes: one silent, the other expressed. Moreover, the two genomes… Expand
Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila
- Joseph N. Fass, N. Joshi, +10 authors K. Collins
- Biology, Medicine
- G3: Genes | Genomes | Genetics
- 1 November 2011
Genetically programmed DNA rearrangements can regulate mRNA expression at an individual locus or, for some organisms, on a genome-wide scale. Ciliates rely on a remarkable process of whole-genome… Expand