E. Ongini

Publications282
h-index56
Citations10,223
Highly Influential Citations299
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The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.
TLDR
Data show that SCH 58261 is a potent and selective non-xanthine A2a adenosine antagonist which has competitive properties in biological responses mediated by this receptor subtype.
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis.
TLDR
PPIs exacerbate NSAID-induced intestinal damage at least in part because of significant shifts in enteric microbial populations, and prevention or reversal of this dysbiosis may be a viable option for reducing the incidence and severity of NSAID enteropathy.
Interleukin‐10 modulates neuronal threshold of vulnerability to ischaemic damage
TLDR
A potential neuroprotective role of IL‐10 against cerebral ischaemia when administered exogenously or made available from endogenous sources is suggested.
Pharmacology of adenosine A2A receptors.
The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 receptor knockout mice
TLDR
Exogenous adenosine acting at striatal A2ARs may be most accurately viewed as a facilitative modulator of striatal neuronal activity rather than simply as an inhibitorymodulator of D2R neurotransmission.
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
TLDR
Blood levels of NDGA or aspirin and its salicylic acid metabolite suggest that the observed lack of effects of ND GA or aspirin on lifespan in females could be related to gender differences in drug disposition or metabolism, and further studies are warranted to find whether NDGA, over a range of doses, might prove to postpone death and various age‐related outcomes reproducibly in mice.
Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models.
Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury.
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors
TLDR
Data indicate that SCH 58261 is the most selective A2A antagonist currently available, and the different receptor selectivity of these three chemically related compounds provides useful information to progress with structure-activity relationship studies.
Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
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