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Human Platelet Dense Granules Contain Polyphosphate and Are Similar to Acidocalcisomes of Bacteria and Unicellular Eukaryotes*
Inorganic polyphosphate (polyP) has been identified and measured in human platelets. Millimolar levels (in terms of Pi residues) of short chain polyP were found. The presence of polyP of ∼70–75Expand
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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
  • R. Guo, R. Cao, +11 authors A. Wang
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 June 2007
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we showExpand
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A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus,Expand
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Diterpene cyclases and the nature of the isoprene fold
The structures and mechanism of action of many terpene cyclases are known, but no structures of diterpene cyclases have yet been reported. Here, we propose structural models based on bioinformatics,Expand
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Corrigendum: Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
Nat. Cell Biol. 14, 257–265 (2012); published online 12 February 2012; corrected after print 26 February 2015 The version of this Article originally published should have acknowledged that this workExpand
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Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
The effects of a series of 102 bisphosphonates on the inhibition of growth of Entamoeba histolytica and Plasmodium falciparum in vitro have been determined, and selected compounds were furtherExpand
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Antiinfectives targeting enzymes and the proton motive force
Significance Uncoupling agents might be expected to be generally cytotoxic, but many US Food and Drug Administration (FDA)-approved drugs do have activity as uncouplers, in addition to targetingExpand
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Reduced cell proliferation by IKK2 depletion in a mouse lung cancer model
Lung cancer is one of the leading cancer malignancies, with a five-year survival rate of only ∼15%. We have developed a lentiviral-vector-mediated mouse model, which enables generation ofExpand
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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
We have investigated the effects in vitro of a series of bisphosphonates on the proliferation of Trypanosoma cruzi, Trypanosoma brucei rhodesiense, Leishmania donovani, Toxoplasma gondii, andExpand
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The Farnesyl-diphosphate/Geranylgeranyl-diphosphate Synthase of Toxoplasma gondii Is a Bifunctional Enzyme and a Molecular Target of Bisphosphonates*
Farnesyl-diphosphate synthase (FPPS) catalyzes the synthesis of farnesyl diphosphate, an important precursor of sterols, dolichols, ubiquinones, and prenylated proteins. We report the cloning andExpand
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