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Nocistatin, a peptide that blocks nociceptin action in pain transmission
Prolonged tissue damage or injury often leads to chronic pain states such that noxious stimuli evoke hyperalgesia and innocuous tactile stimuli evoke pain (allodynia),. The neuropeptide nociceptin,,Expand
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N‐ethylmaleimide‐sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation
Central sensitization, similar to long‐term potentiation in the hippocampus, refers to the increased synaptic efficacy established in somatosensory neurons in the dorsal horn of the spinal cordExpand
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Involvement of primary afferent C‐fibres in touch‐evoked pain (allodynia) induced by prostaglandin E2
Nociceptive primary afferents have the capacity to induce a state of increased excitability in dorsal horn neurons of the spinal cord or central sensitization causing thermal hyperalgesia andExpand
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Characterization of nociceptin hyperalgesia and allodynia in conscious mice
Intrathecal (i.t.) administration of nociceptin and high doses of morphine induced allodynia in response to innocuous tactile stimuli, and i.t. nociceptin evoked hyperalgesia in response to noxiousExpand
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Characterization of the glutamatergic system for induction and maintenance of allodynia
Glutamate is the main excitatory neurotransmitter in the central nervous system and has been shown to be involved in spinal nociceptive processing. We previously demonstrated that intrathecal (i.t.)Expand
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Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC‐801 is mediated by inhibition of nitric oxide production
At the spinal level, the involvement of nociceptin/orphanin FQ (N/OFQ) in pain transmission is controversial. JTC‐801, a selective nonpeptidergic N/OFQ antagonist, is a good tool to examine theExpand
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Cytotoxic effect of spermine on retinal pigment epithelial cells.
PURPOSE A prior study showed inactivation of ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells by a specific irreversible inhibitorExpand
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Pituitary Adenylate Cyclase-Activating Polypeptide Is Required for the Development of Spinal Sensitization and Induction of Neuropathic Pain
The prolonged sensitization of pain transmission after nerve injury by increasing excitability of spinal neurons and thereby promoting repair is an adaptive response of the body. The neuropeptideExpand
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Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor
We identified a novel neuropeptide and named it "nocistatin." Its presence was expected by analysis of the precursor for the neuropeptide nociceptin or orphanin FQ (Noc/OFQ), previously identified asExpand
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Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
We previously reported that intrathecal administration of prostaglandin (PG) D2 and PGE2 to conscious mice induced hyperalgesia (assessed by a hot-plate test) and that intrathecal administration ofExpand
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