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Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.
The results demonstrate that KF-14363 is a compound that has a protective effect against the damage induced in various experimental liver injury models with different mechanisms.
Effects of KF-14363 on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride.
- I. Yoshitake, E. Ohishi, J. Sano, T. Mori, K. Kubo
- Biology, ChemistryJournal of pharmacobio-dynamics
- 1 December 1991
The results show that KF-14363 inhibits liver fibrosis in a dose dependent fashion in rats with progressive liver injury.
Effects of 1-[(2-thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) on liver regeneration and function of hepatic mitochondria…
Effects of 1-[(2-Thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363), a hepatoprotective compound, on liver regeneration, liver…
Qualitative and quantitative characterization of Fas (CD95) expression and its role in primary human acute leukemia cells.
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides.
2-bromo-N-(2,6-diisopropylphenyl)-6,11-dihydrodibenz-[b,e]++ +oxepin-11- carboxamide (33, KF17828) showed significant in vitro activity and the most potent in vivo activity (complete reduction in elevated serum total cholesterol levels at a dose of 10 mg/kg in hamsters).
N-(1-phenyl-2-benzimidazolyl)-N′-phenylurea derivatives as potent in hibitors of acylcoa:cholesterol acyltransferase (ACAT)
Inhibitors of acyl-CoA: cholesterol acyltransferase. II. Preparation and hypocholesterolemic activity of optically active dibenz[b,e]oxepin-11-carboxanilides.
The enantiomer (-)-1 showed potent ACAT inhibitory activity in vitro with an IC50 value of 8 nM and was approximately 10-fold more active than (+)-1 and strong hypocholesterolemic activity in vivo, whereas (+-1 was inactive.
Effects of KW-3033, a novel inhibitor of acylCoA cholesterol acyltransferase, on efflux of cholesterol in macrophages
Inhibitors of Acyl-CoA:Cholesterol Acyltransferase (ACAT). Part 1. Synthesis and Hypocholesterolemic Activity of Dibenz(b,e)oxepin-11- carboxanilides.