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Nutraceuticals: opening the debate for a regulatory framework
- A. Santini, S. Cammarata, +4 authors E. Novellino
- British journal of clinical pharmacology
- 14 February 2018
Currently, nutraceuticals do not have a specific definition distinct from those of other food‐derived categories, such as food supplements, herbal products, pre‐ and probiotics, functional foods, and… Expand
Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase.
Vascular smooth muscle cell (VSMC) proliferation contributes to vascular remodeling in atherosclerosis and hypertension. Calcium-dependent signaling through calcium/calmodulin-dependent kinase II… Expand
An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis.
- F. Lolli, B. Mulinacci, +16 authors A. M. Papini
- Proceedings of the National Academy of Sciences…
- 19 July 2005
Multiple sclerosis (MS) is a complex disease that seems to depend on several pathophysiological processes. Because of its varied clinical presentation, natural history, and response to therapeutic… Expand
Online comprehensive RPLC × RPLC with mass spectrometry detection for the analysis of proteome samples.
LC-MS-based shotgun proteomics relies both on the power of the separation techniques and the sensitivity of detection methods. As a viable alternative to classical approaches in this field, we… Expand
Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors
Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides… Expand
Nutraceutical potential and antioxidant benefits of red pitaya (Hylocereus polyrhizus) extracts
Polyphenols from flesh and peels of red pitaya (Hylocereus polyrhizus) fruit were quantified by employing an extract sub-fractionation procedure applied for the first time to this fruit. Higher… Expand
Nutraceuticals: A paradigm of proactive medicine
&NA; Nutraceuticals define a new category which shades the frontier between drugs and food. As per its definition, a nutraceutical is “a food or part of a food that provides benefits health in… Expand
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells
- S. Valente, Y. Liu, +19 authors A. Mai
- Chemistry, Medicine
- Journal of medicinal chemistry
- 4 January 2014
DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of gene expression and represent valuable targets in cancer chemotherapy. A number of nucleoside DNMT inhibitors… Expand
Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca).
- G. C. Tenore, P. Campiglia, P. Stiuso, A. Ritieni, E. Novellino
- Medicine, Chemistry
- Food chemistry
- 15 October 2013
The capacities of polyphenolic extracts from Annurca apple peel and flesh to inhibit the glucose and cholesterol uptake by HepG2 cells were evaluated, and compared with those of other conventional… Expand
Nutraceutical potential of monofloral honeys produced by the Sicilian black honeybees (Apis mellifera ssp. sicula).
- G. C. Tenore, A. Ritieni, P. Campiglia, E. Novellino
- Biology, Medicine
- Food and chemical toxicology : an international…
- 1 June 2012
In the light of the growing interest in food and food products obtained through organic and environmentally friendly techniques, the present work represents the first approach to the evaluation of… Expand