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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.
Protein misfolding and the formation of aggregates are increasingly recognized components of the pathology of human genetic disease and hallmarks of many neurodegenerative disorders. As exemplifiedExpand
C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
Inclusions in the brain containing α-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We haveExpand
Polyglutamine protein aggregates are dynamic
Protein aggregation and the formation of inclusion bodies are hallmarks of the cytopathology of neurodegenerative diseases, including Huntington's disease, Amyotropic lateral sclerosis, Parkinson'sExpand
Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins.
Heat shock proteins interact with multiple key components of signaling pathways that regulate growth and development. The molecular relationships between heat shock proteins, various signalingExpand
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Abstractl-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp metabolism inExpand
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α‐synuclein complex by Hip
The ATP‐dependent protein chaperone heat‐shock protein 70 (Hsp70) displays broad anti‐aggregation functions and has a critical function in preventing protein misfolding pathologies. According to inExpand
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-related neurological diseases like Parkinson and Alzheimer’s diseases. Here, we identify tryptophanExpand
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
An approved anticancer drug selectively targets the first step in the molecular cascade resulting in Alzheimer’s disease. The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates isExpand
An open source platform for analyzing and sharing worm behavior data
We have developed an open resource to begin addressing these challenges using worm tracking as a model for analyzing and sharing behavior data. Expand
In Vivo Chaperone Activity of Heat Shock Protein 70 and Thermotolerance
ABSTRACT Heat shock protein 70 (Hsp70) is thought to play a critical role in the thermotolerance of mammalian cells, presumably due to its chaperone activity. We examined the chaperone activity andExpand