• Publications
  • Influence
D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
  • E. Noble
  • Medicine
  • American journal of medical genetics. Part B…
  • 2003
The D2 dopamine receptor (DRD2) has been one of the most extensively investigated gene in neuropsychiatric disorders. After the first association of the TaqI A DRD2 minor (A1) allele with severeExpand
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Allelic association of human dopamine D2 receptor gene in alcoholism.
In a blinded experiment, we report the first allelic association of the dopamine D2 receptor gene in alcoholism. From 70 brain samples of alcoholics and nonalcoholics, DNA was digested withExpand
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Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review
  • E. Noble
  • Psychology, Medicine
  • European Psychiatry
  • 1 March 2000
Summary Since 1990, association studies have amassed strong evidence implicating the D2 dopamine receptor (DRD2) gene in alcoholism. Specifically, the Taql A minor (A1) allele of the DRD2 gene hasExpand
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D2 and D4 dopamine receptor polymorphisms and personality.
The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptorExpand
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Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
Recent studies suggest that genetic and environmental factors do not account for all the schizophrenia risk, and epigenetics also has a role in disease susceptibility. DNA methylation is a heritableExpand
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Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.
The allelic association of the human D2 dopamine receptor gene with the binding characteristics of the D2 dopamine receptor was determined in 66 brains of alcoholic and non-alcoholic subjects. In aExpand
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Association of Seven Polymorphisms of the D2 Dopamine Receptor Gene with Brain Receptor-Binding Characteristics
Association of alleles at the Taql A, Taql B, intron 6, Taql D, exon 7, exon 8, and promoter-141C sites of the D2 dopamine receptor gene with D2 dopamine receptor binding characteristics in theExpand
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A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.
Abstract A simple and direct method of labelling brain norepinephrine stores, via injection into the lateral ventricle is described. H 3 -norepinephrine introduced by this procedure was found to beExpand
  • 541
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Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism.
In a blinded study, 159 subjects composed of nonalcoholics (N = 43), less severe alcoholics (N = 44), severe alcoholics (N = 52) and young children of alcoholics (CoAs, N = 20) were studied for theirExpand
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The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment.
A total of 95 Caucasian opioid-dependent patients were followed over a one-year period in an outpatient methadone treatment program. The frequency of the TaqI A(1) allele of the D(2) dopamineExpand
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