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Single-molecule FRET reveals sugar-induced conformational dynamics in LacY
The N- and C-terminal six-helix bundles of lactose permease (LacY) form a large internal cavity open on the cytoplasmic side and closed on the periplasmic side with a single sugar-binding site at theExpand
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Introducing improved structural properties and salt dependence into a coarse-grained model of DNA.
We introduce an extended version of oxDNA, a coarse-grained model of deoxyribonucleic acid (DNA) designed to capture the thermodynamic, structural, and mechanical properties of single- andExpand
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Photochemical selectivity in guanine-cytosine base-pair structures.
Prebiotic chemistry presumably took place before formation of an oxygen-rich atmosphere and thus under conditions of intense short wavelength UV irradiation. Therefore, the UV photochemical stabilityExpand
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Properties of isolated DNA bases, base pairs and nucleosides examined by laser spectroscopy
Abstract:The vibronic spectra of laser desorbed and jet cooled guanine (G) adenine (A), and cytosine (C) consist of bands from four, two and two major tautomers respectively, as revealed by UV-UV andExpand
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REMPI spectroscopy of cytosine
We report resonant two-photon ionization spectra of laser desorbed, jet cooled, cytosine, 1-methyl cytosine, 5-methyl cytosine, and dimers of these. Unlike other pyrimidine bases, cytosine exhibitsExpand
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On the Photochemistry of Purine Nucleobases
We present R2PI spectra of a series of purine nucleobases, nucleosides, and related derivatives, including adenine, guanine, guanosine, 2-aminopurine, 2,6-diaminopurine, 9-ethyladenine, andExpand
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Guanine tautomerism revealed by UV–UV and IR–UV hole burning spectroscopy
The vibronic spectrum of laser desorbed and jet cooled guanine consists of bands from three different tautomers of guanine as revealed by UV–UV and IR–UV double resonance spectroscopy.Expand
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Site‐specific labeling of proteins for single‐molecule FRET by combining chemical and enzymatic modification
An often limiting factor for studying protein folding by single‐molecule fluorescence resonance energy transfer (FRET) is the ability to site‐specifically introduce a photostable organic FRET donorExpand
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IR–UV double-resonance spectroscopy of the nucleobase adenine
We present R2PI and IR–UV double resonance spectra of the nucleobase adenine seeded in a supersonic jet. We show that there is only one tautomer of adenine which absorbs in the wavelength range 36Expand
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Pairing of isolated nucleobases: double resonance laser spectroscopy of adenine-thymine.
The vibronic spectrum of the adenine-thymine (A-T) base pair was obtained by one-color resonant two-photon ionization (R2PI) spectroscopy in a free jet of thermally evaporated A and T underExpand
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