• Publications
  • Influence
The porcine lung as a potential model for cystic fibrosis.
Airway disease currently causes most of the morbidity and mortality in patients with cystic fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing novel therapeuticExpand
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Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.
RATIONALE Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize theExpand
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In vivo micro-CT lung imaging via a computer-controlled intermittent iso-pressure breath hold (IIBH) technique.
Respiratory research with mice using micro-computed tomography (micro-CT) has been predominantly hindered by the limited resolution and signal-to-noise ratio (SNR) as a result of respiratory motionExpand
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Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment?
The change in alveolar size and number during the full breathing cycle in mammals remains unanswered, yet these descriptors are fundamental for understanding alveolar-based diseases and for improvingExpand
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Lung structure phenotype variation in inbred mouse strains revealed through in vivo micro-CT imaging.
Within pulmonary research, the development of mouse models has provided insight into disease development, progression, and treatment. Structural phenotypes of the lung in healthy inbred mouse strainsExpand
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Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs
Significance Mucociliary transport (MCT) defends lungs by removing particulates, and defective MCT is hypothesized to contribute to the onset of lung diseases such as asthma, chronic bronchitis, andExpand
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Longitudinal assessment of lung cancer progression in the mouse using in vivo micro-CT imaging.
PURPOSE Small animal micro-CT imaging is being used increasingly in preclinical biomedical research to provide phenotypic descriptions of genomic models. Most of this imaging is coincident withExpand
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An Automated Segmentation Approach for Highlighting the Histological Complexity of Human Lung Cancer
Lung cancer nodules, particularly adenocarcinoma, contain a complex intermixing of cellular tissue types: incorporating cancer cells, fibroblastic stromal tissue, and inactive fibrosis. QuantitativeExpand
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Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section
Optical coherence tomography (OCT) allows tissue histologic‐like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroidExpand
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Large Image Microscope Array for the Compilation of Multimodality Whole Organ Image Databases
Three‐dimensional, structural and functional digital image databases have many applications in education, research, and clinical medicine. However, to date, apart from cryosectioning, there have beenExpand
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