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A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety
CL 218,872 is the first non-benzodiazepine to selectively displace brain specific 3H-diazepam binding with a potency comparable to that of the benzodiazepines. Like the benzodiazepines, CL 218,872Expand
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The Photoactivated Relaxation of Smooth Muscle of Rabbit Aorta
Smooth muscle of strips of rabbit aorta, placed in a state of active tonic contraction by addition of a stimulating drug, relaxes during exposure to light. The relaxation is reversible. The extent ofExpand
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Correlations of activating and lethal effects of excitatory drugs in grouped and isolated mice.
A study was undertaken to determine whether stimulants other than sympathomimetic amines showed an increased lethal action in grouped mice compared to isolated mice. The associations amongst drugExpand
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Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines.
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines (VIII) is reported. Some of these derivatives show activity in tests predictive of anxiolytic activity [(a)Expand
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The neuropharmacological actions of amoxapine.
Amoxapine possesses a broad spectrum of psychotropic actions, including antidepressant and neuroleptic effects in animals. Antidepressant activity is characterized by its ability to inhibitExpand
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Derivatives of 1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione as anxiolytic agents.
A study of the pharmacological properties of pyrrolo[2,1-c][1,4]benzodiazepine derivatives led to the choice ofExpand
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Aryl-s-tetrazines with antiinflammatory activity.
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Derivatives of 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine as central nervous system agents
Four 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepines were prepared and evaluated as central nervous system agents. All were active psychotropic agents as determined by animal screeningExpand
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Is dopamine antagonism a requisite of neuroleptic activity?
Neuroleptic activity in laboratory animals is characterized by a decrease in locomotor activity, ptosis, catalepsy, antagonism of certain amphetamine-induced responses, and inhibition of aExpand
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