• Publications
  • Influence
Basic local alignment search tool.
A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP)Expand
Genome sequencing in microfabricated high-density picolitre reactors
TLDR
A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described. Expand
The genome sequence of Drosophila melanogaster.
TLDR
The nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome is determined using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Expand
The Sequence of the Human Genome
TLDR
Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated. Expand
Suffix arrays: a new method for on-line string searches
TLDR
A new and conceptually simple data structure, called a suffixarray, for on-line string searches is introduced in this paper, and it is believed that suffixarrays will prove to be better in practice than suffixtrees for many applications. Expand
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
TLDR
It is proposed that liquid-like compartments carry the trade-off between functionality and risk of aggregation and that aberrant phase transitions within liquid- like compartments lie at the heart of ALS and, presumably, other age-related diseases. Expand
The whole genome assembly of Drosophila
  • E. Myers
  • Computer Science, Medicine
  • SODA '00
  • 1 February 2000
TLDR
The quality of a whole-genome assembly of Drosophila melanogaster and the nature of the computer algorithms that accomplished it are reported on and should be of substantial value to the scientific community. Expand
Optimal alignments in linear space
TLDR
The goal of this paper is to give Hirschberg's idea the visibility it deserves by developing a linear-space version of Gotoh's algorithm, which accommodates affine gap penalties. Expand
Evolution of genes and genomes on the Drosophila phylogeny
TLDR
These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Expand
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