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CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
TLDR
This multicenter study found that CSF Abeta42, T-t Tau, and P-tau identify incipient AD with good accuracy, but less accurately than reported from single-center studies. Expand
Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors.
There are five subtypes of muscarinic acetylcholine receptors (M(1) to M(5)) which control a large number of physiological processes, such as the function of heart and smooth muscles, glandularExpand
Inhibition of acetylcholine muscarinic M1 receptor function by the M1‐selective ligand muscarinic toxin 7 (MT‐7)
TLDR
It is concluded that MT‐7 acts as a selective noncompetitive antagonist of the muscarinic M1 receptors by binding stably to an allosteric site. Expand
CSF amyloid-β and tau proteins, and cognitive performance, in early and untreated Parkinson's Disease: the Norwegian ParkWest study
TLDR
CSF Aβ levels are altered in a subset of patients with early PD and relate to memory impairment, and alterations in Aβ protein metabolism may contribute to the heterogeneity in pattern and course of cognitive decline associated with PD. Expand
CSF amyloid β38 as a novel diagnostic marker for dementia with Lewy bodies
TLDR
This study suggests that the level of Aβ38 can potentially contribute in the diagnostic distinction between AD and DLB when combined with Aβ42, suggesting that developing a panel of markers is the most promising strategy. Expand
Neuropsychiatric Correlates of Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease
TLDR
The finding suggests that apathy is associated with the level of neurofibrillary tangles in people with mild Alzheimer’s disease, indicating that other brain changes contribute to these symptoms. Expand
Age and diagnostic performance of Alzheimer disease CSF biomarkers
TLDR
Although the diagnostic accuracies for AD decreased with age, the predictive values for a combination of biomarkers remained essentially stable, and support the use of CSF biomarkers for AD even in older populations. Expand
Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates
TLDR
The differential association between sAPPα and sAPPβ with Aβ and Tau species between LBD and AD groups suggests a possible relationship with the underlying pathologies in LBD or AD. Expand
Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method
TLDR
The present study used immunoprecipitation combined with nanoflow liquid chromatography coupled to high resolution electrospray ionization Fourier transform ion cyclotron resonance tandem mass spectrometry (ESI-FTICR-MS/MS) to determine known and novel isoforms of α-syn in brain tissue homogenates. Expand
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