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Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons
Significance Fragile X syndrome (FXS), the most frequent form of inherited intellectual disability, is caused by the absence of the protein Fragile X Mental Retardation Protein (FMRP) in neurons. InExpand
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Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome
22q11.2 deletion syndrome (22q11DS) is associated with learning and cognitive dysfunctions and a high risk of developing schizophrenia. It has become increasingly clear that dendritic spineExpand
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Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)
Background: Rich2 is a synaptic Rho-GAP (Rho-GTPase-activating protein) the target of which was unknown. Results: We found that Rich2 controls dendritic spine morphogenesis by inhibiting Rac1Expand
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Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons
Neuronal hippocampal cultures are simple and valuable models for studying neuronal function. While embryonic cultures are widely used for different applications, mouse postnatal cultures are stillExpand
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PNAS Plus Significance Statements
Many immune responses are mediated by direct cell–cell interactions and develop over multiple timescales. A mechanistic understanding of how diverse outcomes arise during these interactions entailsExpand