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Microstructure of a spatial map in the entorhinal cortex
TLDR
The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment. Expand
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
TLDR
These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3. Expand
Frequency of gamma oscillations routes flow of information in the hippocampus
TLDR
The results point to routeing of information as a possible function of gamma frequency variations in the brain and provide a mechanism for temporal segregation of potentially interfering information from different sources. Expand
Path integration and the neural basis of the 'cognitive map'
TLDR
Theoretical studies suggest that the medial entorhinal cortex might perform some of the essential underlying computations by means of a unique, periodic synaptic matrix that could be self-organized in early development through a simple, symmetry-breaking operation. Expand
Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex
TLDR
The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion–based navigation. Expand
The entorhinal grid map is discretized
TLDR
It is shown with recordings from up to 186 grid cells in individual rats that grid cells cluster into a small number of layer-spanning anatomically overlapping modules with distinct scale, orientation, asymmetry and theta-frequency modulation, raising the possibility that the modularity of the grid map is a product of local self-organizing network dynamics. Expand
Representation of Geometric Borders in the Entorhinal Cortex
TLDR
The existence of an entorhinal cell type that fires when an animal is close to the borders of the proximal environment is reported, and border cells may be instrumental in planning trajectories and anchoring grid fields and place fields to a geometric reference frame. Expand
Functional organization of the hippocampal longitudinal axis
TLDR
Together, anatomical studies and electrophysiological recordings in rodents suggest a model in which functional long-axis gradients are superimposed on discrete functional domains, which provides a potential framework to explain and test the multiple functions ascribed to the hippocampus. Expand
Hippocampal remapping and grid realignment in entorhinal cortex
TLDR
The nature of hippocampal remapping can be predicted by ensemble dynamics in place-selective grid cells in the medial entorhinal cortex, one synapse upstream of the hippocampus, and is shown to be associated with stable grid fields. Expand
Place cells, grid cells, and the brain's spatial representation system.
TLDR
How place cells and grid cells may form the basis for quantitative spatiotemporal representation of places, routes, and associated experiences during behavior and in memory is reviewed. Expand
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