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- Influence
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the… Expand
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
- E. Morrison, Patty T Wai, +6 authors R. Natrajan
- Biology, Medicine
- Journal of visualized experiments : JoVE
- 26 December 2016
The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets.… Expand
Chronic Peripheral Treatment with Mediated Loss following - Oxidative Stress Dopaminergic Neurons Contributes to Their 1 Expression in α Cutting Edge: IL-13R
- P. Maher, S. Sugama, +6 authors M. Marcondes
- Medicine
- 2012
- 1
Projected sensitivity of the LUX-ZEPLIN experiment to the 0νββ decay of Xe 136
- D. S. Akerib, C. Akerlof, +189 authors P. Zarzhitsky
- Physics
- 9 December 2019
Author(s): Akerib, DS; Akerlof, CW; Alqahtani, A; Alsum, SK; Anderson, TJ; Angelides, N; Araujo, HM; Armstrong, JE; Arthurs, M; Bai, X; Balajthy, J; Balashov, S; Bang, J; Baxter, A; Bensinger, J;… Expand
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
- B. Peck, P. Bland, +39 authors R. Natrajan
- Medicine
- Cancer Research
- 28 January 2021
This study demonstrates that CREBBP genomic alterations drive aggressive TNBC, lung cancer, and lymphomas and may be selectively treated with clinical CDK4/6 inhibitors. Triple-negative breast… Expand
Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
- Haoran Tang, Leo Leung, +10 authors R. Marais
- Chemistry, Medicine
- Nature Communications
- 18 July 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer
- B. Peck, P. Bland, +13 authors R. Natrajan
- Medicine
- 1 July 2018
Solid tumors display significant histological, genetic and micro-environmental intra-tumor heterogeneity that can change substantially over the course of their evolutionary trajectory. In particular,… Expand
Lysyl oxidase regulates EGFR signalling through the extracellular matrix
- Haoran Tang, Leo Leung, +8 authors R. Marais
- Chemistry
- 1 July 2016
UK Breast Cancer Research Symposium 2016: Submitted Abstracts
- Sarah L. Maguire, E. Morrison, +38 authors A. Tutt
- Medicine
- Breast Cancer Research and Treatment
- 2016
UK Breast Cancer Research Symposium 2016: Submitted Abstracts The Author(s) 2016. This article is published with open access at Springerlink.com Breast cancer risk alleles in separate gene regulatory… Expand