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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates theExpand
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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets.Expand
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Projected sensitivity of the LUX-ZEPLIN experiment to the 0νββ decay of Xe 136
Author(s): Akerib, DS; Akerlof, CW; Alqahtani, A; Alsum, SK; Anderson, TJ; Angelides, N; Araujo, HM; Armstrong, JE; Arthurs, M; Bai, X; Balajthy, J; Balashov, S; Bang, J; Baxter, A; Bensinger, J;Expand
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3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
This study demonstrates that CREBBP genomic alterations drive aggressive TNBC, lung cancer, and lymphomas and may be selectively treated with clinical CDK4/6 inhibitors. Triple-negative breastExpand
Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer
Solid tumors display significant histological, genetic and micro-environmental intra-tumor heterogeneity that can change substantially over the course of their evolutionary trajectory. In particular,Expand
UK Breast Cancer Research Symposium 2016: Submitted Abstracts
UK Breast Cancer Research Symposium 2016: Submitted Abstracts The Author(s) 2016. This article is published with open access at Springerlink.com Breast cancer risk alleles in separate gene regulatoryExpand