E. Mor ton Bradbury

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Well-defined genome architecture in the human sperm nucleus

Andrei O. Zalensky, M Jeannie Allen, A. Kobayashi, Irina A. Zalenskaya, Reiner Balhorn, E. Mor ton Bradbury
Chromosoma
1995

Using fluorescence in situ hybridization, conventional epifluorescence microscopy, and laser scanning confocal microscopy followed by three-dimensional reconstruction we describe a well-defined… (More)

Histone acetylation reduces nucleosome core particle linking number change.

Victor Norton, Brian S. Imai, Peter Yau, E. Mor ton Bradbury
Cell
1989

Nucleosome core particles differing in their levels of histone acetylation have been formed on a closed circular DNA that contains a tandemly repeated 207 bp nucleosome positioning sequence. The… (More)

Sequence-specific packaging of DNA in human sperm chromatin.

Justin Gatewood, Gary J. Cook, Reiner Balhorn, E. Mor ton Bradbury, C. W. Schmid
Science
1987

The DNA in human sperm chromatin is packaged into nucleoprotamine (approximately 85%) and nucleohistone (approximately 15%). Whether these two chromatin fractions are sequence-specific subsets of the… (More)

Mobility of positioned nucleosomes on 5 S rDNA.

Sebastiaan W. C. Pennings, Geert Meersseman, E. Mor ton Bradbury
Journal of molecular biology
1991

We report on a dynamic aspect of nucleosome positioning, in the absence of transcription-related events, on sea urchin 5 S rDNA. On tandem repeats of nucleosome length DNA of this strongly… (More)

Telomere-telomere interactions and candidate telomere binding protein(s) in mammalian sperm cells.

Andrei O. Zalensky, Nikolay V. Tomilin, Irina A. Zalenskaya, Raymond L. Teplitz, E. Mor ton Bradbury
Experimental cell research
1997

We have used fluorescent in situ hybridization to localize telomeres within the nuclei of sperm from six mammals (human, rat, mouse, stallion, boar, and bull). In minimally swollen sperm of mouse and… (More)

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

David Gadbois, Harry A. Crissman, R. A. Tobey, E. Mor ton Bradbury
Proceedings of the National Academy of Sciences…
1992

We have shown that nontransformed mammalian cells arrest early in the G1 phase of the cell cycle when treated with exceedingly low concentrations of the nonspecific kinase inhibitor staurosporine,… (More)

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product.

John P.H. Th'ng, P. S. Wright, +4 authors E. Mor ton Bradbury
Cell
1990

The mouse cell FT210 was isolated as a G2 phase mutant with a possible defect in the histone H1 kinase. We determined that a temperature-sensitive lesion in this cell line lies in the CDC2 gene. DNA… (More)

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

S. R. Peterson, Akihiro Kurimasa, Miyuki Oshimura, Wffliam S Dynan, E. Mor ton Bradbury, D. J. Chen
Proceedings of the National Academy of Sciences…
1995

The DNA-dependent protein kinase (DNA-PK) consists of three polypeptide components: Ku-70, Ku-80, and an approximately 350-kDa catalytic subunit (p350). The gene encoding the Ku-80 subunit is… (More)

Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

Igor B Nazarov, Anastasija Smirnova, +8 authors Nikolay V. Tomilin
Radiation research
2003

The induction of DNA double-strand breaks (DSBs) by ionizing radiation in mammalian chromosomes leads to the phosphorylation of Ser-139 in the replacement histone H2AX, but the molecular mechanism(s)… (More)

Acetylation of histone H4 and its role in chromatin structure and function.

S. S. Chahal, H. R. Matthews, E. Mor ton Bradbury
Nature
1980

Histone h4 is a highly conserved structural component of the nucleosome subunit of chromatin. The activation of chromatin is accompanied by changes in structure which may be caused by histone… (More)

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